α玉米赤霉醇
α玉米赤霉醇结构式
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常用名 | α玉米赤霉醇 | 英文名 | Zeranol |
|---|---|---|---|---|
| CAS号 | 26538-44-3 | 分子量 | 322.396 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 576.0±50.0 °C at 760 mmHg | |
| 分子式 | C18H26O5 | 熔点 | 178 - 185ºC | |
| MSDS | 中文版 美版 | 闪点 | 207.9±23.6 °C | |
| 符号 |
GHS02, GHS07 |
信号词 | Danger |
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Simultaneous determination of six resorcylic acid lactones in feed using liquid chromatography-tandem mass spectrometry and multi-walled carbon nanotubes as a dispersive solid phase extraction sorbent.
J. Chromatogr. A. 1307 , 41-8, (2013) A simple and cost-effective pre-treatment procedure was developed for six resorcylic acid lactones (RALs) in feed using dispersive solid phase extraction (dSPE) with multi-walled carbon nanotubes (MWCNTs). The sample was analysed after purification by ultra-h... |
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Effect of zeranol on expression of apoptotic and cell cycle proteins in murine placentae.
Toxicology 314(1) , 148-54, (2013) Mycotoxins are chemicals produced by fungus and many of them are toxic to humans. Zeranol is a mycotoxin used to promote growth in cattle in North America; yet such a practice draws concern about the residual compound in meat in European countries. In the pre... |
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Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships.
J. Nat. Prod. 74 , 1126-31, (2011) As part of our ongoing investigation of filamentous fungi for anticancer leads, an active fungal extract was identified from the Mycosynthetix library (MSX 63935; related to Phoma sp.). The initial extract exhibited cytotoxic activity against the H460 (human ... |
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Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
J. Nat. Prod. 69 , 178-84, (2006) In an effort to discover small molecule inhibitors of Hsp90, we have screened over 500 EtOAc extracts of Sonoran desert plant-associated fungi using a two-stage strategy consisting of a primary cell-based heat shock induction assay (HSIA) followed by a second... |
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Cellular mechanisms of the cytotoxic effects of the zearalenone metabolites α-zearalenol and β-zearalenol on RAW264.7 macrophages.
Toxicol. In Vitro 27(3) , 1007-17, (2013) Zearalenone (ZEN) and its metabolites are commonly found in many food commodities and are known to cause reproductive disorders and genotoxic effects. The major ZEN metabolites are α-zearalenol (α-ZOL) and β-zearalenol (β-ZOL). Although many studies have demo... |
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Zeranol upregulates corticotropin releasing hormone expression in the placental cell line JEG-3
Toxicol. Lett. 219(3) , 218-22, (2013) • Zeranol induced CRH mRNA expression in JEG-3 cells at sub-nM range. • ERK and PKCδ in the placental cells were activated. • CRE-binding activity in the CRH gene promoter was increased. |
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The role of α-zearalanol in reversing bone loss induced by ovarian hormone deficiency in rats.
J. Bone Miner. Metab. 30(2) , 136-43, (2012) To assess the ability of α-zearalanol (α-ZAL) to prevent bone loss in an ovariectomized (OVX) rat model of osteoporosis, α-ZAL was administered intragastrically to rats. After 35 days, the total body bone mineral density (BMD) was assessed in all rats. All se... |
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Three-dimensional dynamic culture of pre-osteoblasts seeded in HA-CS/Col/nHAP composite scaffolds and treated with α-ZAL.
Acta Biochim. Biophys. Sin. (Shanghai) 44(8) , 669-77, (2012) Pre-osteoblast MC3T3-E1 cells were cultured in hyaluronic acid-modified chitosan/collagen/nano-hydroxyapatite (HA-CS/Col/nHAP) composite scaffolds and treated with phytoestrogen α-zearalanol (α-ZAL) to improve bone tissue formation for bone tissue engineering... |
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Urinary mycoestrogens, body size and breast development in New Jersey girls.
Sci. Total Environ. 409(24) , 5221-7, (2011) Despite extensive research and interest in endocrine disruptors, there are essentially no epidemiologic studies of estrogenic mycotoxins, such as zeranol and zearalenone (ZEA). ZEA mycoestrogens are present in grains and other plant foods through fungal conta... |
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Preparation of highly specific anti-zearalenone antibodies by using the cationic protein conjugate and development of an indirect competitive enzyme-linked immunosorbent assay.
Analyst 137(1) , 229-36, (2012) Although anti-zearalenone (ZEN) antibodies have been widely prepared, these antibodies cross-react with α-zearalenol (α-ZOL), β-zearalenol (β-ZOL), zearalanone (ZAN), α-zearalanol (α-ZAL) and β-zearalanol (β-ZAL). To overcome this problem and improve the spec... |