安丝菌素P3
安丝菌素P3结构式
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常用名 | 安丝菌素P3 | 英文名 | Ansamitocin P-3 |
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| CAS号 | 66584-72-3 | 分子量 | 635.145 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 833.1±65.0 °C at 760 mmHg | |
| 分子式 | C32H43ClN2O9 | 熔点 | 190-192℃ | |
| MSDS | 中文版 美版 | 闪点 | 457.7±34.3 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Enhanced production of ansamitocin P-3 by addition of isobutanol in fermentation of Actinosynnema pretiosum.
Bioresour. Technol. 102 , 1863-1868, (2011) Supply of isobutanol to enhance the production of anti-tumor agent ansamitocin P-3 (AP-3) in medium containing agro-industrial residues was investigated with analysis of gene transcription, enzyme activity, and intermediate accumulation. Under the optimal add... |
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Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins.
Chem. Biol. 15(8) , 863-74, (2008) Ansamitocins are potent antitumor maytansinoids produced by Actinosynnema pretiosum. Their biosynthesis involves the initial assembly of a macrolactam polyketide, followed by a series of postpolyketide synthase (PKS) modifications. Three ansamitocin glycoside... |
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Determination of the cryptic stereochemistry of the first PKS chain-extension step in ansamitocin biosynthesis by Actinosynnema pretiosum.
ChemBioChem. 7(8) , 1221-5, (2006) The biosynthesis of the antitumor antibiotic, ansamitocin, involves the assembly of a linear octaketide on the ansamitocin (asm) polyketide synthase (PKS), which is then cyclized to proansamitocin and further modified to the final product. In the first chain-... |
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Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst.
ChemBioChem. 11(18) , 2517-20, (2010)
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Bioreduction of aryl azides during mutasynthesis of new ansamitocins.
Org. Lett. 15(17) , 4442-5, (2013) Supplementing a culture of a mutant strain of Actinosynnema pretiosum that is unable to biosynthesize aminohydroxy benzoic acid (AHBA), with 3-azido-5-hydroxy-benzoic acid and 3-azido-5-amino-benzoic acid, unexpectedly yielded anilino ansamitocins instead of ... |
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Enhanced production of ansamitocin P-3 by addition of Mg2+ in fermentation of Actinosynnema pretiosum.
Bioresour. Technol. 102(21) , 10147-50, (2011) The effect of divalent metal ions (i.e., Mn(2+), Mg(2+), Zn(2+), Cu(2+), and Co(2+)) on the production of anticancer ansamitocin P-3 (AP-3) by submerged cultures of Actinosynnema pretiosum in medium containing agro-industrial residues was investigated, and Mg... |
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Constitutive overexpression of asm2 and asm39 increases AP-3 production in the actinomycete Actinosynnema pretiosum.
J. Ind. Microbiol. Biotechnol. 36(11) , 1345-51, (2009) Constitutive overexpression of regulators in the ansamitocin biosynthetic cluster of Actinosynnema pretiosum was investigated as a strategy to increase the production of ansamitocin-P3 (AP-3), a clinically promising chemotherapeutic agent. Putative transcript... |
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A novel amide N-glycoside of ansamitocins from Actinosynnema pretiosum.
J. Antibiot. 57(5) , 348-50, (2004)
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Dual Carbamoylations on the Polyketide and Glycosyl Moiety by Asm21 Result in Extended Ansamitocin Biosynthesis
Chem. Biol. 18(12) , 1571-80, (2011) Carbamoylation is one of the post-PKS modifications in ansamitocin biosynthesis. A novel ansamitocinoside with carbamoyl substitution at the C-4 hydroxyl group of the N-β-D-glucosyl moiety was identified from the ansamitocin producer, Actinosynnema pretiosum.... |
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New amide N-glycosides of ansamitocins identified from Actinosynnema pretiosum.
Arch. Pharm. Res. 30(6) , 670-3, (2007) By using preparative TLC as the critical isolation procedure, two compounds, including one new amide N-glycosides of ansamitocin (2), were isolated from Actinosynnema pretiosum. The compounds were elucidated as N-demethyl-N-beta-D-glucopyranosyl ansamitocin P... |