右盐酸芬氟拉明

Int. J. Clin. Pract. Suppl. (156) , 27-31, (2007)

In the 1960s, serotonin (5HT) was associated with pulmonary arterial hypertension (PAH) caused by certain diet pills, but has recently been the subject of renewed interest in the field of PAH. Serotonin can be synthesised in the pulmonary endothelium with the...

Proc. Natl. Acad. Sci. U. S. A. 106(26) , 10528-33, (2009)

O(2) reactivity of a functional NOR model is investigated by using electrochemistry and spectroscopy. The electrochemical measurements using interdigitated electrodes show very high selectivity for 4e O(2) reduction with minimal production of partially reduce...

Chem. Commun. (Camb.) 47(3) , 973-5, (2011)

The S-peptide and S-protein components of bovine pancreatic ribonuclease form a noncovalent complex with restored ribonucleolytic activity. Although this archetypal protein-fragment complementation system has been the object of historic work in protein chemis...

Psychopharmacology 199(4) , 583-92, (2008)

Procedures for studying the effects of medications on satiation will assist the development of obesity medications.Develop a procedure for measuring satiation during consumption of bland and highly palatable food and determine the effect of acute intramuscula...

Physiol. Behav. 103(5) , 493-500, (2011)

We examined the effects of periodic access to a palatable, high sugar content food (candy) in 8 male baboons on the anorectic response to d-amphetamine, which increases dopamine, and dexfenfluramine, which increases serotonin. During candy access, up to 200 c...

Eur. J. Pharmacol. 579(1-3) , 215-24, (2008)

We document in vitro and in vivo effects of a novel, selective cannabinoid CB(1) receptor inverse agonist, Imidazole 24b (5-(4-chlorophenyl)-N-cyclohexyl-4-(2,4-dichlorophenyl)-1-methyl-imidazole-2-carboxamide). The in vitro binding affinity of Imidazole 24b ...

Comp. Biochem. Physiol. A. Mol. Integr. Physiol. 166(1) , 186-90, (2013)

Mammalian studies have shown a link between serotonin (5-HT) and neuropeptide Y (NPY) in the acute regulation of feeding and energy homeostasis. Taking into account that the actions of 5-HT and NPY on food intake in fish are similar to those observed in mamma...

Eur. J. Pharmacol. 602(2-3) , 355-63, (2009)

The anorectic drug, dexfenfluramine has been associated with an increase in the relative risk of developing pulmonary hypertension. 5-hydroxytryptamine (5-HT) is a mitogen for smooth muscle cell, an effect that relies on 5-HT transporter expression and which ...

Pharmacol. Biochem. Behav. 90(3) , 339-43, (2008)

In the 1990s, phentermine was combined with either fenfluramine or its active enantiomer dexfenfluramine to promote weight loss. Appetite suppressants are known to alter pain reactivity. The current experiment examined the acute impact of phentermine (0, 2.5,...

Nat. Rev. Drug Discov. 7(12) , 961-2, (2008)

A wave of terminations of development programmes for cannabinoid receptor 1 blockers for obesity indicates the demise of a drug class that was once anticipated to yield blockbusters. Nevertheless, lessons learned might help salvage something for future such a...