(R)-2-羟基丁酸
(R)-2-羟基丁酸结构式
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常用名 | (R)-2-羟基丁酸 | 英文名 | (R)-2-HYDROXYBUTYRIC ACID |
|---|---|---|---|---|
| CAS号 | 20016-85-7 | 分子量 | 104.10 | |
| 密度 | 1.195g/cm3 | 沸点 | 238.3ºC at 760 mmHg | |
| 分子式 | C4H8O3 | 熔点 | 50-54ºC | |
| MSDS | 中文版 美版 | 闪点 | 112.2ºC | |
| 符号 |
GHS05, GHS07 |
信号词 | Danger |
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(1)H NMR-based metabonomic investigation of the effect of two different exercise sessions on the metabolic fingerprint of human urine.
J. Proteome Res. 9(12) , 6405-16, (2010) Physical exercise modifies animal metabolism profoundly. Until recently, biochemical investigations related to exercise focused on a small number of biomolecules. In the present study, we used a holistic analytical approach to investigate changes in the human... |
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Kinetic resolution of 2-hydroxybutanoate racemic mixtures by NAD-independent L-lactate dehydrogenase.
Bioresour. Technol. 102(7) , 4595-9, (2011) Optically active D-2-hydroxybutanoate is an important building block intermediate for medicines and biodegradable poly(2-hydroxybutanoate). Kinetic resolution of racemic 2-hydroxybutanoate may be a green and desirable alternative for D-2-hydroxybutanoate prod... |
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Metabolic characterisation of plasma in juveniles with glycogen storage disease type 1a (GSD1a) by high-resolution (1)H NMR spectroscopy.
NMR Biomed. 20(4) , 401-12, (2007) This paper reports the first application of high-resolution (1)H NMR spectroscopy to the plasma of five juveniles with glycogen storage disease type 1a (GSD1a), permitting the characterisation of the plasma metabolic profile and the identification of alterati... |
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Prospective study of changes in the metabolomic profiles of men during their first three months of androgen deprivation therapy for prostate cancer.
Clin. Cancer Res. 18(13) , 3677-85, (2012) Androgen deprivation therapy (ADT) for prostate cancer causes an increase in fasting insulin and adverse changes in body composition and serum lipid profile. It is unknown what other metabolic alterations are caused by ADT. To better characterize the metaboli... |
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Clinical applications of urinary organic acids. Part I: Detoxification markers.
Altern. Med. Rev. 13(3) , 205-15, (2008) Modern instrumentation allows the measurement of organic acids in urine in their physiological concentration ranges. Eight of the compounds that are reported can serve as markers for specific toxicant exposure or detoxification challenges. Xylene exposure cau... |
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Enantiomeric separation and discrimination of 2-hydroxy acids as O-trifluoroacetylated (S)-(+)-3-methyl-2-butyl esters by achiral dual-capillary column gas chromatography.
J. Chromatogr. A. 874(1) , 91-100, (2000) An efficient method is described for the simultaneous enantiomeric separation of 18 different racemic 2-hydroxy acids for the determination of their absolute configurations. It involves the conversion of each enantiomer into a diastereomeric O-trifluoroacetyl... |
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Perturbing the hydrophobic pocket of mandelate racemase to probe phenyl motion during catalysis.
Biochemistry 44(25) , 9013-21, (2005) Mandelate racemase (MR, EC 5.1.2.2) from Pseudomonas putida catalyzes the Mg(2+)-dependent 1,1-proton transfer that interconverts the enantiomers of mandelate. Crystal structures of MR reveal that the phenyl group of all ground-state ligands is located within... |
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Inhibition and regulation of rat liver L-threonine dehydrogenase by different fatty acids and their derivatives.
Biochim. Biophys. Acta 1568(1) , 45-52, (2001) Rat liver L-threonine dehydrogenase is a mitochondrial enzyme which transforms L-threonine either into aminoacetone or into acetyl-CoA. We show that it is inhibited by several fatty acids and their derivatives: short chain fatty acids, L-2-hydroxybutyrate and... |
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Inhibition of citrate oxidation in vitro by 2-hydroxybutyrate and 4-hydroxybutyrate in cerebral cortex of young rats.
Biochem. Soc. Trans. 23(2) , 229S, (1995)
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Synthesis of all four stereoisomers of 3-amino-2-hydroxybutanoic acids.
Biosci. Biotechnol. Biochem. 68(3) , 714-20, (2004) All four stereoisomers of 3-amino-2-hydroxybutanoic acids were been obtained as single enantiomers via stereospecific reactions from D-gulonic acid gamma-lactone and D-glucono-delta-lactone. |