金刚烷胺
金刚烷胺结构式
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常用名 | 金刚烷胺 | 英文名 | Adamantan-1-amine |
|---|---|---|---|---|
| CAS号 | 768-94-5 | 分子量 | 151.249 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 225.7±8.0 °C at 760 mmHg | |
| 分子式 | C10H17N | 熔点 | 206-208 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 96.0±9.7 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Differential effects of viroporin inhibitors against feline infectious peritonitis virus serotypes I and II.
Arch. Virol. 160(5) , 1163-70, (2015) Feline infectious peritonitis virus (FIP virus: FIPV), a feline coronavirus of the family Coronaviridae, causes a fatal disease called FIP in wild and domestic cat species. The genome of coronaviruses encodes a hydrophobic transmembrane protein, the envelope ... |
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CDDP supramolecular micelles fabricated from adamantine terminated mPEG and β-cyclodextrin based seven-armed poly (L-glutamic acid)/CDDP complexes.
Colloids Surf. B Biointerfaces 105 , 31-6, (2013) This research is aimed to develop a nano-sized supramolecular micelle delivery system of cis-dichlorodiammine platinum (II) (CDDP) in order to achieve the passive tumor targeting. Firstly, star-shaped poly (γ-benzyl-L-glutamate) was synthesized by the ring-op... |
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A primary fish gill cell culture model to assess pharmaceutical uptake and efflux: evidence for passive and facilitated transport.
Aquat. Toxicol. 159 , 127-37, (2015) The gill is the principle site of xenobiotic transfer to and from the aqueous environment. To replace, refine or reduce (3Rs) the large numbers of fish used in in vivo uptake studies an effective in vitro screen is required that mimics the function of the tel... |
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Stereoselective synthesis and pharmacological evaluation of [4.3.3]propellan-8-amines as analogs of adamantanamines.
Bioorg. Med. Chem. 23 , 4277-85, (2015) Amantadine (1) exerts its anti-Parkinson effects by inhibition of the NMDA associated cation channel and its antiviral activity by inhibition of the M2 protein channel of influenza A viruses. Herein the synthesis, NMDA receptor affinity and anti-influenza act... |
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Therapeutic potential of antiviral drugs targeting chemorefractory colorectal adenocarcinoma cells overexpressing endogenous retroviral elements.
J. Exp. Clin. Cancer Res 34 , 81, (2015) Endoretroviruses account for circa 8 % of all transposable elements found in the genome of humans and other animals. They represent a genetic footprint of ancestral germ-cell infections of exoviruses that is transmittable to the progeny by Mendelian segregati... |
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Rapid determination of memantine in human plasma by using nanoring carboxyl-functionalized paramagnetic molecularly imprinted polymer d-μ-SPE and UFLC-MS/MS.
Drug Test. Anal. 7 , 535-43, (2015) A novel, simple, and sensitive method based on the use of dispersive micro-solid-phase extraction (d-μ-SPE) procedure combined with ultra-fast liquid chromatography-tandem quadrupole mass spectrometry (UFLC-MS/MS) for the determination of memantine (ME) was d... |
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Enantioselective analysis of D- and L-amino acids from mouse macrophages using high performance liquid chromatography.
J. Pharm. Biomed. Anal. 116 , 101-4, (2015) The intrinsic D-amino acid profile of mouse macrophages extracted from the peritoneal cavity was analyzed using high performance liquid chromatography. Six D-amino acids (D-Asp, D-Ser, D-Ala, D-Leu, D-Gln and D-Lys) were detected in cell lysates of mouse macr... |
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Attenuation of vesicular stomatitis virus infection of brain using antiviral drugs and an adeno-associated virus-interferon vector.
Virology 475 , 1-14, (2014) Vesicular stomatitis virus (VSV) shows promise as a vaccine-vector and oncolytic virus. However, reports of neurotoxicity of VSV remain a concern. We compared 12 antiviral compounds to control infection of VSV-CT9-M51 and VSV-rp30 using murine and human brain... |
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Synthesis and characterization of a new Peptide prodrug of glucosamine with enhanced gut permeability.
PLoS ONE 10 , e0126786, (2015) The aim of this study was to synthesize a peptide prodrug of glucosamine (GlcN) with increased gut permeability through the gut peptide transporter 1 (PepT1). Glycine-Valine ester derivative of GlcN (GVG) was synthesised using solid phase synthesis followed b... |
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Predicting the development of levodopa-induced dyskinesias: a presynaptic mechanism?
Neurology 82(18) , 1574-5, (2014) After chronic levodopa use, many patients with Parkinson disease (PD) develop involuntary movements. Whether disabling or minor, levodopa-induced dyskinesia (LID) constitutes an undesirable outcome calling for better treatment strategies. Options for managing... |