DL-4-溴苯丙氨酸

FEBS Lett. 467(1) , 37-40, (2000)

Artificial proteins can be engineered to exhibit interesting solid state, liquid crystal or interfacial properties and may ultimately serve as important alternatives to conventional polymeric materials. The utility of protein-based materials is limited, howev...

FEBS Lett. 364(3) , 272-5, (1995)

It has previously been demonstrated that the unnatural amino acid p-Cl-phenylalanine can be attached to tRNA(Phe) by a modified phenylalanyl-tRNA synthetase with relaxed amino acid substrate specificity. We show that this modification to the translational mac...

Basic Life Sci. 50 , 219-32, (1989)

Basic Life Sci. 50 , 69-73, (1989)

Basic Life Sci. 50 , 63-7, (1989)

Proc. Natl. Acad. Sci. U. S. A. 103(17) , 6483-8, (2006)

Recently, tRNA aminoacyl-tRNA synthetase pairs have been evolved that allow one to genetically encode a large array of unnatural amino acids in both prokaryotic and eukaryotic organisms. We have determined the crystal structures of two substrate-bound Methano...

J. Am. Chem. Soc. 128(36) , 11778-83, (2006)

Introduction of a yeast suppressor tRNA (ytRNA(Phe)(CUA)) and a mutant yeast phenylalanyl-tRNA synthetase (yPheRS (T415G)) into an Escherichia coli expression host allows in vivo incorporation of phenylalanine analogues into recombinant proteins in response t...

Biotechnol. Bioeng. 110(9) , 2361-70, (2013)

Enzyme inhibition plays an important role in drug development, metabolic pathway regulation, and biocatalysis with product inhibition. When an inhibitor has high structural similarities to the substrate of an enzyme, controlling inhibitor binding without affe...

Biochemistry 32(12) , 3067-76, (1993)

The very strong helical propensity of peptides rich in alpha-aminoisobutyric acid (Aib) has enabled the design of a set of helices containing as guest amino acids one fluorescent chromophore, beta-(1'-naphthyl)-L-alanine, and one heavy atom perturber, p-bromo...