4-苯基咪唑
4-苯基咪唑结构式
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常用名 | 4-苯基咪唑 | 英文名 | 4-PHENYLIMIDAZOLE |
|---|---|---|---|---|
| CAS号 | 670-95-1 | 分子量 | 144.17 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 379.8±11.0 °C at 760 mmHg | |
| 分子式 | C9H8N2 | 熔点 | 128-131 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 213.0±5.7 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention.
Pharmacol. Res. 100 , 135-47, (2015) Two new analogues of CDDO-Imidazolide (CDDO-Im), namely 1-[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4(-pyridin-2-yl)-1H-imidazole ("CDDO-2P-Im") and 1-[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4(-pyridin-3-yl)-1H-imidazole ("CDDO-3P-Im") have been s... |
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Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.
Antimicrob. Agents Chemother. 51 , 3915-23, (2007) Sterol 14alpha-demethylase (CYP51), a major checkpoint in membrane sterol biosynthesis, is a key target for fungal antibiotic therapy. We sought small organic molecules for lead candidate CYP51 inhibitors. The changes in CYP51 spectral properties following li... |
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Calmodulin-dependent nitric-oxide synthase. Mechanism of inhibition by imidazole and phenylimidazoles.
J. Biol. Chem. 268(13) , 9425-9, (1993) Calmodulin-dependent nitric-oxide synthase from bovine brain and GH3 pituitary cells is inhibited by imidazole, 1-phenylimidazole, 2-phenylimidazole, and 4-phenylimidazole, with half-maximal inhibition occurring at 200, 25, 160, and 600 microM concentrations ... |
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Bindings of axial ligands to cytochrome P-450d mutants: a difference absorption spectral study.
Biochim. Biophys. Acta 995(2) , 116-21, (1989) By site-directed mutagenesis, we made several cytochrome P-450d (P-450d) mutants as follows: Asn310Phe (D13), Ile312Leu (D14), Glu318Asp (D15), Val320Ile (D16), Phe325Thr (D19), Asn310Phe,Ile312Leu (M6), Glu318Asp,Val320Ile (M7), Phe325Thr, Glu318Asp (M3). Th... |
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Theoretical study of the ligand-CYP2B4 complexes: effect of structure on binding free energies and heme spin state.
Proteins 55(4) , 895-914, (2004) The molecular origins of temperature-dependent ligand-binding affinities and ligand-induced heme spin state conversion have been investigated using free energy analysis and DFT calculations for substrates and inhibitors of cytochrome P450 2B4 (CYP2B4), employ... |
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Enzyme kinetic and spectroscopic studies of inhibitor and effector interactions with indoleamine 2,3-dioxygenase. 1. Norharman and 4-phenylimidazole binding to the enzyme as inhibitors and heme ligands.
Biochemistry 28(13) , 5392-9, (1989) The effects of norharman, one of the few known inhibitors of the heme protein indoleamine 2,3-dioxygenase, and of 4-phenylimidazole (4-PheImid), a heme ligand, on the catalytic (Vmax, Km) and spectroscopic properties (optical absorption, CD, and magnetic CD) ... |
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Spectral and metabolic properties of liver microsomes from imidazole-pretreated rabbits.
Biochem. Biophys. Res. Commun. 108(2) , 664-72, (1982)
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New imidazoles as probes of the active site topology and potent inhibitors of beta-glucosidase.
J. Biochem. 123(3) , 416-22, (1998) Series of 4-arylimidazoles, omega-N-acylhistamines and 4-(omega-phenylalkyl)imidazoles were synthesized in order to probe the active site topology of sweet almond beta-glucosidase. These imidazole derivatives were shown to be very powerful competitive inhibit... |
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4-Phenyl-1H-imidazole (a low-temperature redetermination), 1-benzyl-1H-imidazole and 1-mesityl-1H-imidazole.
Acta Crystallogr. C 60(Pt 8) , o542-4, (2004)
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Ligand-assisted inhibition in cytochrome P450 158A2 from Streptomyces coelicolor A3(2).
Biochemistry 45(24) , 7493-500, (2006) Cytochrome P450 158A2 (CYP158A2) can polymerize flaviolin to red-brown pigments, which may afford physical protection to the organism, possibly against the deleterious effects of UV radiation. We have found that the small molecule malonic acid enables cocryst... |