琥珀酸二甲酯
琥珀酸二甲酯结构式
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常用名 | 琥珀酸二甲酯 | 英文名 | Dimethyl succinate |
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| CAS号 | 106-65-0 | 分子量 | 146.141 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 195.3±0.0 °C at 760 mmHg | |
| 分子式 | C6H10O4 | 熔点 | 16-19 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 85.0±0.0 °C |
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Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition.
PLoS ONE 9(12) , e115144, (2014) Recent work has highlighted glutaminase (GLS) as a key player in cancer cell metabolism, providing glutamine-derived carbon and nitrogen to pathways that support proliferation. There is significant interest in targeting GLS for cancer therapy, although the ge... |
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Process model and economic analysis of itaconic acid production from dimethyl succinate and formaldehyde.
Bioresour. Technol. 97(2) , 342-7, (2006) A complete process model and economic analysis has been developed for itaconic acid production via catalytic condensation of dimethyl succinate and formaldehyde. The process model is based on experimental yields and selectivities obtained for the condensation... |
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Effects of the methyl esters of pyruvate, succinate and glutamate on the secretory response to meglitinide analogues in rat pancreatic islets.
Pharmacol. Res. 33(3) , 191-4, (1996) The insulinotropic action of the meglitinide analogues KAD-1229, A-4166 and repaglinide was examined in rat pancreatic islets deprived of exogenous nutrient or incubated in the presence of nutrient secretagogues such as D-glucose and the methyl esters of pyru... |
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Antimicrobial hydantoin-containing polyesters.
Macromol. Biosci. 12(8) , 1068-76, (2012) A new N-hydantoin-containing biocompatible and enzymatically degradable polyester with antibacterial properties is presented. Different polyesters of dimethyl succinate, 1,4-butanediol, and 3-[N,N-di(β-hydroxyethyl)aminoethyl]-5,5-dimethylhydantoin in varying... |
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Stimulation of insulin release in vivo by the methyl esters of succinic acid and glutamic acid.
Adv. Exp. Med. Biol. 426 , 231-4, (1997)
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Potentiation of the insulinotropic action of GLP-1 by succinic acid dimethyl ester in fed anaesthetized rats.
Horm. Metab. Res. 32(8) , 306-9, (2000) The insulinotropic action of GLP-1 is modulated by the nutritional environment of islet B-cells. This study explores whether an ester of succinic acid could be used to potentiate the insulin secretory response to GLP-1 in vivo. Fed anaesthetized male rats rec... |
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Effects of D-mannoheptulose and its hexaacetate ester on hormonal secretion from the perfused pancreas.
Int. J. Mol. Med. 6(2) , 143-52, (2000) D-mannoheptulose was recently proposed to be transported into cells by GLUT2, whereas its hexaacetate ester may cross the plasma membrane without requiring the intervention of a specific carrier system. In the light of these proposals, the effects of unesteri... |
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Metabolism of the dimethyl ester of [2,3-(13)C]succinic acid in rat hepatocytes.
Mol. Cell Biochem. 189(1-2) , 137-44, (1998) Hepatocytes prepared from overnight fasted rats were incubated for 120 min in the presence of the dimethyl ester of [2,3-(13)C]succinic acid (10 mM). The identification and quantification of 13C-enriched metabolites in the incubation medium were performed by ... |
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Effects of succinate dimethyl ester on the metabolic and hormonal response to exercise in fed and starved rats.
Int. J. Mol. Med. 5(6) , 643-9, (2000) This study aims at investigating the possible beneficial effect of succinic acid dimethyl ester (SAD), injected intraperitoneally (5.0 micromol/g body wt.), upon the metabolic and hormonal response to a 60 min exercise in both fed and overnight starved rats. ... |
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Stimulation of insulin synthesis and release by alpha-D-glucose pentaacetate in pancreatic islets from human subjects.
Horm. Metab. Res. 32(3) , 118-20, (2000)
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