GDP
GDP结构式
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常用名 | GDP | 英文名 | GUANOSINE 5'-DIPHOSPHATE TRIS SALT |
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| CAS号 | 103192-39-8 | 分子量 | 564.33600 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C14H26N6O14P2 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation.
EMBO J. 30 , 3913-3927, (2011) The activation of the Rac1 GTPase during cell signalling entails its translocation from the cytosol to membranes, release from sequestering Rho GDP dissociation inhibitors (RhoGDI), and GDP/GTP exchange. In addition to those steps, we show here that optimal R... |
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RIC8 is a guanine-nucleotide exchange factor for Galpha subunits that regulates growth and development in Neurospora crassa.
Genetics 189 , 165-176, (2011) Heterotrimeric (αβγ) G proteins are crucial components of eukaryotic signal transduction pathways. G-protein-coupled receptors (GPCRs) act as guanine nucleotide exchange factors (GEFs) for Gα subunits. Recently, facilitated GDP/GTP exchange by non-GPCR GEFs, ... |
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Insights into the molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF.
J. Biol. Chem. 286 , 35163-35175, (2011) PDZRhoGEF (PRG) belongs to a small family of RhoA-specific nucleotide exchange factors that mediates signaling through select G-protein-coupled receptors via Gα(12/13) and activates RhoA by catalyzing the exchange of GDP to GTP. PRG is a multidomain protein c... |
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Novel C-terminal motif within Sec7 domain of guanine nucleotide exchange factors regulates ADP-ribosylation factor (ARF) binding and activation.
J. Biol. Chem. 286(42) , 36898-906, (2011) ADP-ribosylation factors (ARFs) and their activating guanine nucleotide exchange factors (GEFs) play key roles in membrane traffic and signaling. All ARF GEFs share a ∼200-residue Sec7 domain (Sec7d) that alone catalyzes the GDP to GTP exchange that activates... |
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The eubacterial protein synthesis inhibitor pulvomycin interacts with archaeal elongation factor 1α from Sulfolobus solfataricus.
Biochimie 94(2) , 503-9, (2011) The effect of pulvomycin on the biochemical and fluorescence spectroscopic properties of the archaeal elongation factor 1α from Sulfolobus solfataricus (SsEF-1α), the functional analog of eubacterial EF-Tu, was investigated. The antibiotic was able to reduce ... |