异丁酰胺结构式
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常用名 | 异丁酰胺 | 英文名 | Isobutyramide |
|---|---|---|---|---|
| CAS号 | 563-83-7 | 分子量 | 87.120 | |
| 密度 | 0.9±0.1 g/cm3 | 沸点 | 221.4±8.0 °C at 760 mmHg | |
| 分子式 | C4H9NO | 熔点 | 127-131 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 87.7±18.4 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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A New Signaling Pathway for HCV Inhibition by Estrogen: GPR30 Activation Leads to Cleavage of Occludin by MMP-9.
PLoS ONE 11 , e0145212, (2016) Poor outcome in response to hepatitis C virus, including higher viral load, hepatocellular carcinoma and cirrhosis, is more associated with men and postmenopausal women than with premenopausal women and women receiving hormone replacement therapy, suggesting ... |
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Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin.
Blood 101(5) , 2001-7, (2003) Pharmacologic stimulation of fetal hemoglobin (HbF) expression may be a promising approach for the treatment of beta-thalassemia. In this study, we have investigated the HbF-inducing activity and molecular mechanisms of specific histone deacetylase (HDAC) inh... |
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Effects of ketoacidosis on rat apolipoprotein A1 gene expression: a link with acidosis but not with ketones.
J. Mol. Endocrinol. 25(1) , 129-39, (2000) To determine if ketoacidosis contributes to reduced apolipoprotein A1 (apoA1) expression in insulin-deficient diabetic rats, we examined the regulation of apoA1 gene expression in response to changes in ambient pH or ketone body concentrations. Hepatic apoAI ... |
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Thermosensitive molecular assemblies from poly(amidoamine) dendron-based lipids.
Angew. Chem. Int. Ed. Engl. 50(28) , 6332-6, (2011)
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Oral isobutyramide reduces transfusion requirements in some patients with homozygous beta-thalassemia.
Blood 96(10) , 3357-63, (2000) The butyrate derivative isobutyramide (IBT) increases fetal hemoglobin (HbF) in patients with beta-hemoglobinopathies, but little is known about its usefulness for prolonged therapeutic use. We treated 8 patients with transfusion-dependent beta-thalassemia wi... |
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Analysis of equilibrium binding data obtained by linear-response spectroscopic techniques.
Anal. Biochem. 224(1) , 330-8, (1995) A new computational approach for the analysis of equilibrium binding data obtained by spectroscopic methods is described. The approach is aimed at systems involving multiple interactions, where the changes in the spectroscopic signal cannot be attributed to a... |
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The importance of alcohol dehydrogenase in regulation of ethanol metabolism in rat liver cells.
Biochem. J. 278 ( Pt 3) , 659-65, (1991) We used titration with the inhibitors tetramethylene sulphoxide and isobutyramide to assess quantitatively the importance of alcohol dehydrogenase in regulation of ethanol oxidation in rat hepatocytes. In hepatocytes isolated from starved rats the apparent Fl... |
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Extremely long protection by pyrazole derivatives against chemically induced gastric mucosal injury.
J. Pharmacol. Exp. Ther. 256(2) , 592-8, (1991) We tested the hypothesis that the gastrotoxicity of ethanol and other damaging agents is influenced through the modulation of alcohol dehydrogenase (ADH) by using either the ADH-inhibitor pyrazole or the noninhibitor derivatives of pyrazole. In time course ex... |
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Discordant effects of butyrate analogues on erythroleukemia cell proliferation, differentiation and histone deacetylase.
Anticancer Res. 15(3) , 879-83, (1995) Actions of butyrate and structural analogues on histone deacetylase activity were compared with effects on proliferation and differentiation of erythroleukemia cells. Proliferation was inhibited by 5 mM tert- butylacetate, phenylacetate, phenylbutyrate, 3-bro... |
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Isobutyramide therapy in patients with sickle cell anemia.
Am. J. Hematol. 49(3) , 244-6, (1995) We have administered Isobutyramide as a suspension over a period of 3 months, from a starting dose of 50 mg/kg/day up to 150 mg/kg/day, to four adult sickle cell (SS) anemia patients. The maximum dose was maintained for 3 weeks. The blood counts remained stab... |