1-氨基芘
1-氨基芘结构式
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常用名 | 1-氨基芘 | 英文名 | aminopyrene |
|---|---|---|---|---|
| CAS号 | 1606-67-3 | 分子量 | 217.265 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 440.8±14.0 °C at 760 mmHg | |
| 分子式 | C16H11N | 熔点 | 115-117 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 246.2±15.4 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Electrochemical polymerization of pyrene derivatives on functionalized carbon nanotubes for pseudocapacitive electrodes.
Nat. Commun. 6 , 7040, (2015) Electrochemical energy-storage devices have the potential to be clean and efficient, but their current cost and performance limit their use in numerous transportation and stationary applications. Many organic molecules are abundant, economical and electrochem... |
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A method for high-throughput, sensitive analysis of IgG Fc and Fab glycosylation by capillary electrophoresis.
J. Immunol. Methods 417 , 34-44, (2015) The N-glycan of the IgG constant region (Fc) plays a central role in tuning and directing multiple antibody functions in vivo, including antibody-dependent cellular cytotoxicity, complement deposition, and the regulation of inflammation, among others. However... |
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Biopartitioning micellar chromatography to predict mutagenicity of aromatic amines.
Eur. J. Med. Chem. 42 , 1396-402, (2007) Mutagenicity is a toxicity endpoint associated with the chronic exposure to chemicals. Aromatic amines have considerable industrial and environmental importance due to their widespread use in industry and their mutagenic capacity. Biopartitioning micellar chr... |
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Quantitative analysis of the mutagenic potential of 1-aminopyrene-DNA adduct bypass catalyzed by Y-family DNA polymerases.
Mutat. Res. 737(1-2) , 25-33, (2012) N-(Deoxyguanosin-8-yl)-1-aminopyrene (dG(AP)) is the predominant nitro polyaromatic hydrocarbon product generated from the air pollutant 1-nitropyrene reacting with DNA. Previous studies have shown that dG(AP) induces genetic mutations in bacterial and mammal... |
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Solution conformation of the N-(deoxyguanosin-8-yl)-1-aminopyrene ([AP]dG) adduct opposite dC in a DNA duplex.
Biochemistry 35(39) , 12659-70, (1996) Combined NMR-molecular mechanics computational studies were undertaken on the C8-deoxyguanosine adduct formed by the carcinogen 1-nitropyrene embedded in the d(C5-[AP]G6-C7).d(G16-C17-G18) sequence context in a 11-mer duplex, with dC opposite the modified deo... |
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Erythrocyte enzymes catalyze 1-nitropyrene and 3-nitrofluoranthene nitroreduction.
Toxicology 108(1-2) , 101-8, (1996) Nitroarenes are environmental contaminants produced during incomplete combustion processes. Nitroreduction, the most important pathway of nitroarene toxification, occurs mainly in the liver and intestine. In the present study, we show that human red cells may... |
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Triple recognition of B-DNA.
Bioorg. Med. Chem. Lett. 19 , 4974-9, (2009) A novel conjugate of Hoechst 33258, pyrene and neomycin was synthesized and examined for its binding and stabilization of A-T rich DNA duplexes using spectroscopic and viscometric techniques. The conjugate, containing three well known ligands that bind nuclei... |
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Quantification of 1-aminopyrene in human urine after a controlled exposure to diesel exhaust.
J. Environ. Monit. 11(1) , 153-9, (2009) Diesel exhaust (DE) is a significant source of air pollution that has been linked to respiratory and cardiovascular morbidity and mortality. Many components in DE, such as polycyclic aromatic hydrocarbons, are present in the environment from other sources. 1-... |
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Differential chemokine induction by 1-nitropyrene and 1-aminopyrene in bronchial epithelial cells: importance of the TACE/TGF-α/EGFR-pathway.
Environ. Toxicol. Pharmacol. 35(2) , 235-9, (2013) 1-nitropyrene (1-NP), a common PAH in diesel exhaust, and its amine metabolite 1-aminopyrene (1-AP) induce distinctly different chemokine-responses in bronchial epithelial cells (BEAS-2B) characterized by increases in CXCL8 and CCL5, respectively. Tumor necro... |
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Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay.
Mutat. Res. 497(1-2) , 223-33, (2001) Metabolic activation of 1-nitropyrene (1-NP) by human cytochrome P450 (P450) family 1 enzymes co-expressed with NADPH-cytochrome P450 reductase (NPR) in Escherichia coli membranes was investigated. 1-NP induced umu gene expression in Salmonella typhimurium TA... |