C-6-G HYDRATE-TRIFLUOROACETATE结构式
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常用名 | C-6-G HYDRATE-TRIFLUOROACETATE | 英文名 | C-6-G HYDRATE-TRIFLUOROACETATE |
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| CAS号 | 20736-11-2 | 分子量 | 475.48800 | |
| 密度 | 1.56g/cm3 | 沸点 | 713.4ºC at 760 mmHg | |
| 分子式 | C24H29NO9 | 熔点 | 248-250ºC (dec.) | |
| MSDS | N/A | 闪点 | 385.2ºC | |
| 符号 |
GHS02, GHS07, GHS08 |
信号词 | Danger |
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Lack of effect of paracetamol on the pharmacokinetics and metabolism of codeine in man.
Eur. J. Clin. Pharmacol. 41(4) , 379-82, (1991) Plasma and urine concentrations of codeine and its measurable metabolites were determined by HPLC in six healthy subjects after a single 30 mg oral dose of codeine either alone or after 7 doses of 1 g paracetamol 8 hourly. After codeine alone, the t1/2 (h), A... |
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Species differences in metabolism of codeine: urinary excretion of codeine glucuronide, morphine-3-glucuronide and morphine-6-glucuronide in mice, rats, guinea pigs and rabbits.
Xenobiotica 20(7) , 683-8, (1990) 1. Metabolites of codeine were determined by use of h.p.l.c. in urine of male mice, rats, guinea pigs and rabbits injected with 10 mg codeine/kg subcutaneously. 2. In 24 h urines of these species, unchanged codeine, codeine glucuronide, free morphine, and mor... |
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Direct determination of codeine, norcodeine, morphine and normorphine with their corresponding O-glucuronide conjugates by high-performance liquid chromatography with electrochemical detection.
J. Chromatogr. A. 570(2) , 309-20, (1991) A high-performance liquid chromatographic method has been developed for the detection, separation and measurement of codeine and its metabolites norcodeine, morphine and normorphine, with their glucuronide conjugates. The glucuronidase Escherichia coli type V... |
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Urine and plasma pharmacokinetics of codeine in healthy volunteers: implications for drugs-of-abuse testing.
J. Anal. Toxicol. 20(7) , 541-6, (1996) Thirteen healthy volunteers participating in an open and randomized study received two single doses (25 and 50 mg) of codeine orally two weeks apart. Urine concentrations of opiates were studied for 96 h, and plasma concentrations of codeine and the metabolit... |
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Pharmacokinetics and metabolism of codeine in humans.
Biopharm. Drug Dispos. 13(6) , 445-60, (1992) Codeine (30 mg phosphate) was metabolized by eight human volunteers to the following six metabolites: codeine-6-glucuronide 81.0 +/- 9.3 per cent, norcodeine 2.16 +/- 1.44 per cent, morphine 0.56 +/- 0.39 per cent, morphine-3-glucuronide 2.10 +/- 1.24 per cen... |
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Evidence for morphine-independent central nervous opioid effects after administration of codeine: contribution of other codeine metabolites.
Clin. Pharmacol. Ther. 79(1) , 35-48, (2006) Our objective was to investigate whether codeine or one of its metabolites contributes substantially to central nervous effects independent from the cytochrome P450 (CYP) 2D6-mediated O-demethylation to morphine.After oral administration of codeine, plasma co... |
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Investigation of morphine and morphine glucuronide levels and cytochrome P450 isoenzyme 2D6 genotype in codeine-related deaths
Forensic Sci. Int. 220(1-3) , 6-11, (2012) Compared to morphine and morphine-6-glucuronide (M6G), codeine and its other major metabolites codeine-6-glucuronide and norcodeine have weak affinity to opioid μ-receptors. Analgesic effects of codeine are thus largely dependent on metabolic conversion to mo... |
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Influence of the CYP2D6 polymorphism and hemodialysis on codeine disposition in patients with end-stage renal disease.
Eur. J. Clin. Pharmacol. 66(3) , 269-73, (2010) We studied the influence of three factors on drug disposition: genetic polymorphism, impaired renal excretion of drug metabolites, and the possible elimination by hemodialysis (HD), using codeine as a model drug.Based on the genotyping of three CYP2D6 polymor... |
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Comparison of the hydrolysis rates of morphine-3-glucuronide and morphine-6-glucuronide with acid and beta-glucuronidase.
J. Anal. Toxicol. 19(3) , 157-62, (1995) The acid and enzymatic hydrolysis rates for two morphine metabolites, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G), were compared. Urine fortified with M3G or M6G was hydrolyzed in a boiling water bath or with beta-glucuronidases. Optimal tem... |
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Analgesic and immunomodulatory effects of codeine and codeine 6-glucuronide.
Pharm. Res. 13(2) , 296-300, (1996) The antinociceptive and immunosuppressive effects of codeine and codeine 6-glucuronide were determined in rats after intracerebroventricular administration.Codeine 6-glucuronide was synthesized using a modification of the Koenigs-Knorr reaction. A lipophilic ... |