谷胱甘肽/5-L-谷氨酰-L-半胱氨酰甘氨酸
谷胱甘肽/5-L-谷氨酰-L-半胱氨酰甘氨酸结构式
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常用名 | 谷胱甘肽/5-L-谷氨酰-L-半胱氨酰甘氨酸 | 英文名 | Glutathione |
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| CAS号 | 70-18-8 | 分子量 | 307.323 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 754.5±60.0 °C at 760 mmHg | |
| 分子式 | C10H17N3O6S | 熔点 | 182-192ºC | |
| MSDS | 中文版 美版 | 闪点 | 410.1±32.9 °C |
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Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.
Biochem. J. 467(2) , 345-52, (2015) Ubiquitylation regulates a multitude of biological processes and this versatility stems from the ability of ubiquitin (Ub) to form topologically different polymers of eight different linkage types. Whereas some linkages have been studied in detail, other link... |
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A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses.
J. Virol. 89(9) , 4918-31, (2015) The ORF45 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus-specific immediate-early tegument protein. Our previous studies have revealed its crucial roles in both early and late stages of KSHV infection. In this study, we survey... |
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Phospho-tyrosine dependent protein-protein interaction network.
Mol. Syst. Biol. 11(3) , 794, (2015) Post-translational protein modifications, such as tyrosine phosphorylation, regulate protein-protein interactions (PPIs) critical for signal processing and cellular phenotypes. We extended an established yeast two-hybrid system employing human protein kinases... |
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High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II.
J. Mol. Cell. Cardiol. 78 , 165-73, (2014) Diet-induced obesity leads to metabolic heart disease (MHD) characterized by increased oxidative stress that may cause oxidative post-translational modifications (OPTM) of cardiac mitochondrial proteins. The functional consequences of OPTM of cardiac mitochon... |
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Disturbed Hsp70 and Hsp27 expression and thiol redox status in porcine kidney PK15 cells provoked by individual and combined ochratoxin A and citrinin treatments.
Food Chem. Toxicol. 71 , 97-105, (2014) The aim of this study was to explore the oxidative properties of ochratoxin A (OTA) and citrinin (CTN) as a possible underlying mechanism of their individual and/or combined cytotoxicity. Metabolic activity of PK15 porcine kidney cells was significantly reduc... |
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Long-chain fatty acid analogues suppress breast tumorigenesis and progression.
Cancer Res. 74(23) , 6991-7002, (2014) Obesity and type 2 diabetes (T2D) are associated with increased breast cancer incidence and mortality, whereas carbohydrate-restricted ketogenic diets ameliorate T2D and suppress breast cancer. These observations suggest an inherent efficacy of nonesterified ... |
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Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells.
Nat. Commun. 6 , 6240, (2015) Epstein-Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection of nasopharyngeal epithelial cells remain elusive. EBV glycoprotein B (gB) is the critical fusion protein f... |
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Protective effects of glucosamine on oxidative-stress and ischemia/reperfusion-induced retinal injury.
Invest. Ophthalmol. Vis. Sci. 56(3) , 1506-16, (2015) To investigate the protective effects of glucosamine (GlcN) using oxidative stress and rat models of ischemia-reperfusion (I/R) injury and to determine the antiapoptotic and anti-inflammatory mechanisms of GlcN treatment.We determined the effects of GlcN and ... |
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Nox2-dependent glutathionylation of endothelial NOS leads to uncoupled superoxide production and endothelial barrier dysfunction in acute lung injury.
Am. J. Physiol. Lung Cell. Mol. Physiol. 307(12) , L987-97, (2014) Microvascular barrier integrity is dependent on bioavailable nitric oxide (NO) produced locally by endothelial NO synthase (eNOS). Under conditions of limited substrate or cofactor availability or by enzymatic modification, eNOS may become uncoupled, producin... |
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DnaJA1/Hsp40 is co-opted by influenza A virus to enhance its viral RNA polymerase activity.
J. Virol. 88(24) , 14078-89, (2014) The RNA-dependent RNA polymerase (RdRp) of influenza A virus is a heterotrimeric complex composed of the PB1, PB2, and PA subunits. The interplay between host factors and the three subunits of the RdRp is critical to enable viral RNA synthesis to occur in the... |