铁螯合剂,Dp44mT
铁螯合剂,Dp44mT结构式
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常用名 | 铁螯合剂,Dp44mT | 英文名 | Dp44mT |
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| CAS号 | 152095-12-0 | 分子量 | 285.367 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 438.4±43.0 °C at 760 mmHg | |
| 分子式 | C14H15N5S | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 218.9±28.2 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells.
Oncotarget 6 , 10374-98, (2015) Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) demonstrates potent anti-cancer activity. We previously demonstrated that 14C-Dp44mT enters and targets cells through a carrier/receptor-mediated uptake process. Despite structural similarity, 2-ben... |
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The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.
Oncotarget 6 , 8851-74, (2015) N-myc downstream regulated gene-1 (NDRG1) is a potent metastasis suppressor that plays a key role in regulating signaling pathways involved in mediating cancer cell invasion and migration, including those derived from prostate, colon, etc. However, the mechan... |
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Involvement of iron depletion in palmitate-induced lipotoxicity of beta cells.
Mol. Cell. Endocrinol. 407 , 74-84, (2015) High levels of plasma free fatty acid are thought to contribute to the loss of pancreatic beta-cells in type 2 diabetes. In particular, saturated fatty acid such as palmitate or stearate can induce apoptosis in cultured beta cells (lipotoxicity). Endoplasmic ... |
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Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes.
Biochem. Pharmacol. 91(3) , 312-22, (2014) Triapine, currently being evaluated as an antitumor agent in phase II clinical trials, and its terminally dimethylated derivative Dp44mT share the α-pyridyl thiosemicarbazone backbone that functions as ligands for transition metal ions. Yet, Dp44mT is approxi... |
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The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway.
Oncotarget 5(18) , 8478-91, (2014) Here we showed that hepatocellular carcinoma (HCC) cell lines with high metastatic potential had low levels of NDRG2. The iron chelator Dp44mT up-regulated NDRG2, suppressed epithelial-mesenchymal transition (EMT) and inhibited tumor metastasis in HCC having ... |
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Trypanotoxic activity of thiosemicarbazone iron chelators.
Exp. Parasitol. 150 , 7-12, (2015) Only a few drugs are available for treating sleeping sickness and nagana disease; parasitic infections caused by protozoans of the genus Trypanosoma in sub-Saharan Africa. There is an urgent need for the development of new medicines for chemotherapy of these ... |
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The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways.
J. Biol. Chem. 291 , 1029-52, (2016) N-MYC downstream-regulated gene-1 (NDRG1) is a potent growth and metastasis suppressor that acts through its inhibitory effects on a wide variety of cellular signaling pathways, including the TGF-β pathway, protein kinase B (AKT)/PI3K pathway, RAS, etc. To in... |