N-乙酰基-L-羟脯氨酸结构式
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常用名 | N-乙酰基-L-羟脯氨酸 | 英文名 | Oxaceprol |
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| CAS号 | 33996-33-7 | 分子量 | 173.167 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 442.1±45.0 °C at 760 mmHg | |
| 分子式 | C7H11NO4 | 熔点 | 132-133 °C (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 221.2±28.7 °C | |
| 符号 |
GHS05 |
信号词 | Danger |
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Oxaceprol, an atypical inhibitor of inflammation, reduces leukocyte adherence in mouse antigen-induced arthritis.
Acta Orthop. Scand. 72(3) , 293-8, (2001) Oxaceprol (N-acetyl-L-hydroxyproline), an atypical inhibitor of inflammation, is an established drug forjoint disease without serious side-effects. Recent studies have emphasized that oxaceprol has an effect on the microcirculation. Since the exact mechanism ... |
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Determination of oxaceprol in rat plasma by LC-MS/MS and its application in a pharmacokinetic study.
J. Pharm. Biomed. Anal. 54(1) , 173-8, (2011) A sensitive method for the quantification of oxaceprol in rat plasma using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed. Sample pretreatment involved a simple protein precipitation by the addition of 60 μL of aceton... |
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[Assessment of the placebo effect of symptomatic slow-acting anti-arthritics].
Presse Med. 27(5) , 211-4, (1998) Assess the importance of the mid-term placebo effect of symptomatic slow acting drugs given for osteoarthritis.We analyzed six controlled trials available in the literature. Trial duration ranged from 2 to 6 months. The trials had been conducted to assess the... |
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Oxaceprol is a well-tolerated therapy for osteoarthritis with efficacy equivalent to diclofenac.
Clin. Rheumatol. 19(2) , 99-104, (2000) The therapeutic equivalence and safety of treatment for 21 days with 400 mg t.i.d. oxaceprol (n = 132) and 50 mg t.i.d. diclofenac (n = 131) were assessed in a multicentre, randomised, double-blind study of a mixed population of patients with osteoarthritis o... |
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Oxaceprol--a randomised, placebo-controlled clinical study in osteoarthritis with a non-conventional non-steroidal anti-inflammatory drug.
Clin. Exp. Rheumatol. 25(1) , 29-34, (2007) To evaluate efficacy of therapy with oxaceprol in the treatment of symptomatic osteoarthritis of knee or hip.A 3-week prospective, multicentric, randomised, double-blind, placebo-controlled study with 167 patients aged between 40 and 75 years with painful and... |
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Oxaceprol is as effective as diclofenac in the therapy of osteoarthritis of the knee and hip.
Clin. Rheumatol. 18(1) , 4-9, (1999) In this multicentre (five centres in Germany), randomised, double-blind, comparative study, 150 patients with painful degenerative joint disease according to EULAR criteria received either oxaceprol (200 mg three times daily) or diclofenac (25 mg three times ... |
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Nutraceuticals in the management of osteoarthritis.
Orthopedics 30(8) , 624-9; quiz 630-1, (2007)
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[Meta-analysis of the efficacy of adenosylmethionine and oxaceprol in the treatment of osteoarthritis].
Orthopade. 31(11) , 1058-65, (2002) The aim of this meta-analysis based on the literature was to gather all evidence of randomized clinical trials to assess the efficacy of adenosylmethionine (SAM) and oxaceprol in the treatment of osteoarthritis. Findings in MEDLINE and EMBASE were added to pu... |
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[Autoradiography studies of the effect of oxaceprol on the metabolism of joint cartilage in vitro and in vivo].
Z. Rheumatol. 46(3) , 136-42, (1987) Using the radiolabelled precursors (3H-Glucosamine, 3H-proline) and a new procedure of quantitative microautoradiography we investigated the influence of N-acetyl-L-hydroxyproline (Oxaceprol) on anabolic processes in joint cartilage tissue of hens. After in v... |
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[The interaction of oxaceprol and fluindione].
Therapie. 45(2) , 162-3, (1990)
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