唑尼沙胺钠

J. Chromatogr. A. 1308 , 25-31, (2013)

A simple, rapid, and efficient method, based on surfactant assisted dispersive liquid-liquid microextraction (SA-DLLME), followed by high performance liquid chromatography (HPLC) has been developed for simultaneous preconcentration and trace detection of zoni...

Acta Neurol. Scand.,. Suppl.c. (194) , 29-35, (2012)

Zonisamide is currently licensed in Europe and the USA for the adjunctive treatment of partial seizures (with or without secondary generalization) in adults, based on the results of four pivotal, randomized, double-blind, placebo-controlled trials. It is also...

Int. J. Eat. Disord. 46(7) , 747-50, (2013)

To assess preliminarily the effectiveness of zonisamide in bulimia nervosa.This was an open-label, prospective, 12-week, flexible dose study of zonisamide in bulimia nervosa. The primary outcome was binge-purge episode frequency.Twelve individuals received zo...

Epilepsy Behav. 26(2) , 170-4, (2013)

The purpose of this study was to evaluate the effects of zonisamide (ZNS) as adjunctive therapy on sleep-wake cycle and daytime somnolence in adult patients affected by focal epilepsy.Thirteen patients affected by focal epilepsy were recruited to undergo a 24...

Epilepsy Behav. 23(4) , 462-5, (2012)

Opinions regarding the impact of antiepileptic drugs (AEDs) on the genesis of psychotic symptoms are varied. To re-examine this issue, the records of adult patients with partial epilepsy and newly added AEDs were retrospectively surveyed. The types of newly a...

Epilepsy Behav. 23(4) , 497-9, (2012)

Because iatrogenic obesity may hinder medication compliance, it would be a reasonable approach to consider antiepileptic drugs (AEDs) that promote weight loss in overweight patients. We performed an open-label, observational study to assess the effects of zon...

Seizure 21(3) , 188-93, (2012)

To evaluate the efficacy and safety of adjunctive zonisamide (ZNS) therapy in Korean adults with uncontrolled partial epilepsy.Study patients had an average of at least one seizure per 4-week (averaged over a 12-week historical baseline) despite the use of on...

Cochrane Database Syst. Rev. 2 , CD007286, (2013)

The incidence of seizures following supratentorial craniotomy for non-traumatic pathology has been estimated to be 15% to 20%; however, the risk of experiencing a seizure may vary from 3% to 92% over a five-year period. Postoperative seizures can precipitate ...

Life Sci. 95(1) , 9-13, (2014)

The purpose of this study was to compare the changes of antihyperalgesic effectiveness of zonisamide (25 and 50 mg/kg), an antiepileptic drug, on the early and late phases of neuropathy and to investigate the role of serotonergic descending inhibitory pain pa...

Biochem. Biophys. Res. Commun. 428(3) , 401-4, (2012)

The anti-epileptic drug zonisamide is reported to exert beneficial effects in patients with Parkinson's disease. To elucidate the pathophysiological mechanisms underlying the anti-parkinsonism effects of zonisamide, we examined the effect of zonisamide co-adm...