7-氨基去乙酰氧基头孢烷酸结构式
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常用名 | 7-氨基去乙酰氧基头孢烷酸 | 英文名 | 7-Aminodeacetoxycephalosporanic acid |
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CAS号 | 22252-43-3 | 分子量 | 214.242 | |
密度 | 1.6±0.1 g/cm3 | 沸点 | 517.6±50.0 °C at 760 mmHg | |
分子式 | C8H10N2O3S | 熔点 | 234ºC (dec.) | |
MSDS | 中文版 美版 | 闪点 | 266.8±30.1 °C | |
符号 |
GHS08 |
信号词 | Danger |
Enhanced enzymatic synthesis of a semi-synthetic cephalosprin, cefaclor, with in situ product removal.
Biotechnol. Lett. 25(14) , 1195-8, (2003) In the enzymatic synthesis of cefaclor, 3-chloro-7-d-(2-phenylglycinamide)-3-cephem-4-carboxylic acid, from phenylglycine methyl ester and 7-aminodesacetoxymethyl-3-chlorocephalosporanic acid, the in situ product could influence both the overall conversion an... |
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Enzymatic production of cephalexin.
Enzyme Microb. Technol. 16(8) , 715-8, (1994) Enzymatic production of cephalexin using immobilized penicillin G acylase was studied. The factors that affect the conversion of 7-amino-3-deacetoxycephalosporanic acid (7-ADCA) to cephalexin, such as pH; temperature; concentrations of 7-ADCA, D(-)-phenylglyc... |
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Continuous cultivations of a Penicillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus: Kinetics of adipoyl-7-aminodeacetoxycephalosporanic acid and byproduct formations.
Biotechnol. Bioeng. 83(3) , 353-60, (2003) The production kinetics of a transformed strain of Penicillium chrysogenum expressing the expandase gene from Streptomyces clavuligerus was investigated in chemostat cultivations. The recombinant strain produces adipoyl-7-aminodeacetoxycephalosporanic acid (a... |
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Environmentally safe production of 7-aminodeacetoxycephalosporanic acid (7-ADCA) using recombinant strains of Acremonium chrysogenum.
Nat. Biotechnol. 18(8) , 857-61, (2000) Medically useful semisynthetic cephalosporins are made from 7-aminodeacetoxycephalosporanic acid (7-ADCA) or 7-aminocephalosporanic acid (7-ACA). Here we describe a new industrially amenable bioprocess for the production of the important intermediate 7-ADCA t... |
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Continuous cultivations of a Penicillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus: Growth yields and morphological characterization.
Biotechnol. Bioeng. 83(3) , 361-8, (2003) The growth stoichiometry of a Penicillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus was determined in glucose-limited chemostat cultivations using a chemically defined medium. This strain produces adipoyl-7-aminodeacetoxy... |
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Process design for enzymatic adipyl-7-ADCA hydrolysis.
Biotechnol. Prog. 18(4) , 745-51, (2002) Adipyl-7-ADCA is a new source for 7-aminodeacetoxycephalosporanic acid (7-ADCA), one of the substrates for antibiotics synthesis. In this paper, a novel process for enzymatic 7-ADCA production is presented. The process consists of a reactor, a crystallization... |
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Penicillin acylase-catalyzed synthesis of beta-lactam antibiotics in highly condensed aqueous systems: beneficial impact of kinetic substrate supersaturation.
Biotechnol. Bioeng. 85(3) , 323-9, (2004) Advantages of performing penicillin acylase-catalyzed synthesis of new penicillins and cephalosporins by enzymatic acyl transfer to the beta-lactam antibiotic nuclei in the supersaturated solutions of substrates have been demonstrated. It has been shown that ... |
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Analysis of a substrate specificity switch residue of cephalosporin acylase.
Biochem. Biophys. Res. Commun. 312(3) , 755-60, (2003) Residue Phe375 of cephalosporin acylase has been identified as one of the residues that is involved in substrate specificity. A complete mutational analysis was performed by substituting Phe375 with the 19 other amino acids and characterising all purified mut... |
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Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase.
Cell. Mol. Life Sci. 58(5-6) , 835-43, (2001) Deacetoxycephalosporin C synthase from Streptomyces clavuligerus catalyses the conversion of the five-membered penicillin ring to the unsaturated six-membered cephem ring of deacetoxycephalosporin C. The effects on enzyme activity of the penicillin substrate ... |
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Quantitative characterization of the nucleophile reactivity in penicillin acylase-catalyzed acyl transfer reactions.
Biochim. Biophys. Acta 1599(1-2) , 134-40, (2002) Nucleophile reactivity of two most known nuclei of penicillins and cephalosporins, 6-aminopenicillanic (6-APA) and 7-aminodesacetoxycephalosporanic (7-ADCA) acids, was quantitatively characterized. In penicillin acylase (PA)-catalyzed acyl transfer reactions ... |