N-烯丙去甲间唑新结构式
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常用名 | N-烯丙去甲间唑新 | 英文名 | n-allylnormetazocine |
|---|---|---|---|---|
| CAS号 | 14198-28-8 | 分子量 | 257.37100 | |
| 密度 | 1.055g/cm3 | 沸点 | 373.6ºC at 760mmHg | |
| 分子式 | C17H23NO | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 169.9ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Sigma-1 receptor stimulation attenuates calcium influx through activated L-type Voltage Gated Calcium Channels in purified retinal ganglion cells.
Exp. Eye Res. 107 , 21-31, (2013) Sigma-1 receptors (σ-1rs) exert neuroprotective effects on retinal ganglion cells (RGCs) both in vivo and in vitro. This receptor has unique properties through its actions on several voltage-gated and ligand-gated channels. The purpose of this study was to in... |
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The C-terminal amidated analogue of the substance P (SP) fragment SP(1-7) attenuates the expression of naloxone-precipitated withdrawal in morphine dependent rats.
Peptides 30 , 2418-2422, (2009) We previously demonstrated that intracerebroventricular (i.c.v.) administration of the substance P (SP) aminoterminal fragment SP(1-7) attenuates the expression of morphine withdrawal in the male rat. In this study we have used a synthetic analogue of this pe... |
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Antagonist action of progesterone at σ-receptors in the modulation of voltage-gated sodium channels.
Am. J. Physiol. Cell Physiol. 300(2) , C328-37, (2011) σ-Receptors are integral membrane proteins that have been implicated in a number of biological functions, many of which involve the modulation of ion channels. A wide range of synthetic ligands activate σ-receptors, but endogenous σ-receptor ligands have prov... |
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Sigma-1 receptor function is critical for both the discriminative stimulus and aversive effects of the kappa-opioid receptor agonist U-50488H.
Addict. Biol. 17(4) , 717-24, (2012) The present study was undertaken to identify possible similarities between the effects of kappa-opioid receptor agonist, N-methyl-D-aspartate-receptor antagonist, and sigma receptor agonist on the discriminative stimulus effects of U-50488H, and the possible ... |
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Sigma1 receptor antagonists determine the behavioral pattern of the methamphetamine-induced stereotypy in mice.
Psychopharmacology 203(4) , 781-92, (2009) The effects of sigma receptor antagonists on methamphetamine (METH)-induced stereotypy have not been examined. We examined the effects of sigma antagonists on METH-induced stereotypy in mice.The administration of METH (10 mg/kg) to male ddY mice induced stere... |
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Age-related expression of sigma1 receptors and antidepressant efficacy of a selective agonist in the senescence-accelerated (SAM) mouse.
J. Neurosci. Res. 79(4) , 561-72, (2005) The sigma1 receptor is a unique intracellular receptor whose activation results in an efficient modulation of several neurotransmitter responses. Its role as a target for the rapid nongenomic effects of neuro(active)steroids and the age-related diminutions in... |
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Inhibition of hyperpolarization-activated cation currents by phencyclidine and some sigma ligands in rat hippocampal CA1 pyramidal neurons in vitro.
Neuropharmacology 53(3) , 406-14, (2007) Using whole-cell voltage-clamp recordings, hyperpolarization-activated cation currents (Ih) were elicited with hyperpolarizing voltage jumps in CA1 pyramidal neurons of rat hippocampal slices, and the effects of phencyclidine (PCP) and some sigma ligands on I... |
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Effects of (+)SKF 10047, a sigma-1 selective agonist, on isolation-induced aggression in male mice.
Methods Find. Exp. Clin. Pharmacol. 28(9) , 601-4, (2006) sigma-1 Receptors have been identified in numerous brain regions, including areas such as hypothalamus and amygdala, which have long been linked to the regulation of aggression. However, there is no clear information with respect to the possible effects of si... |
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Phenytoin differentially modulates the affinity of agonist and antagonist ligands for sigma 1 receptors of guinea pig brain.
Synapse 55(3) , 192-5, (2005) We evaluated the effects of phenytoin (DPH) on the affinity for sigma-1 (sigma(1)) receptors of agonist or antagonist sigma(1) ligands in guinea pig brain. Heterologous competition experiments showed that DPH (250 microM and 1 mM) concentration-dependently in... |
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Sigma-1 receptor agonists directly inhibit Nav1.2/1.4 channels.
PLoS ONE 7(11) , e49384, (2012) (+)-SKF 10047 (N-allyl-normetazocine) is a prototypic and specific sigma-1 receptor agonist that has been used extensively to study the function of sigma-1 receptors. (+)-SKF 10047 inhibits K(+), Na(+) and Ca2+ channels via sigma-1 receptor activation. We fou... |