6-氮尿嘧啶结构式
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常用名 | 6-氮尿嘧啶 | 英文名 | 6-Azauracil |
|---|---|---|---|---|
| CAS号 | 461-89-2 | 分子量 | 113.07 | |
| 密度 | 1.9±0.1 g/cm3 | 沸点 | 503.4ºC at 760 mmHg | |
| 分子式 | C3H3N3O2 | 熔点 | 274-275 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 258.3ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Rad9 interacts with Aft1 to facilitate genome surveillance in fragile genomic sites under non-DNA damage-inducing conditions in S. cerevisiae.
Nucleic Acids Res. 42(20) , 12650-67, (2014) DNA damage response and repair proteins are centrally involved in genome maintenance pathways. Yet, little is known about their functional role under non-DNA damage-inducing conditions. Here we show that Rad9 checkpoint protein, known to mediate the damage si... |
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Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4.
Genes Dev. 22(20) , 2786-98, (2008) Set2-mediated H3 K36 methylation is an important histone modification on chromatin during transcription elongation. Although Set2 associates with the phosphorylated C-terminal domain (CTD) of RNA polymerase II (RNAPII), the mechanism of Set2 binding to chroma... |
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Overruling the energy gap law: fast triplet formation in 6-azauracil.
Phys. Chem. Chem. Phys. 12(48) , 15665-71, (2010) The photophysical properties of 6-azauracil were studied by means of ab initio quantum chemical methods. On the basis of our calculations we propose here the following mechanism for the lack of fluorescence and the high triplet quantum yield that was observed... |
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Separable functions of the fission yeast Spt5 carboxyl-terminal domain (CTD) in capping enzyme binding and transcription elongation overlap with those of the RNA polymerase II CTD.
Mol. Cell. Biol. 30(10) , 2353-64, (2010) An interaction network connecting mRNA capping enzymes, the RNA polymerase II (Pol II) carboxyl-terminal domain (CTD), elongation factor Spt5, and the Cdk7 and Cdk9 protein kinases is thought to comprise a transcription elongation checkpoint. A crux of this n... |
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TFIIS is required for the balanced expression of the genes encoding ribosomal components under transcriptional stress.
Nucleic Acids Res. 40(14) , 6508-19, (2012) Transcription factor IIS (TFIIS) stimulates RNA cleavage by RNA polymerase II by allowing backtracked enzymes to resume transcription elongation. Yeast cells do not require TFIIS for viability, unless they suffer severe transcriptional stress due to NTP-deple... |
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Comprehensive structural studies of 2',3'-difluorinated nucleosides: comparison of theory, solution, and solid state.
J. Am. Chem. Soc. 130(28) , 9048-57, (2008) The conformations of three 2',3'-difluoro uridine nucleosides were studied by X-ray crystallography, NMR spectroscopy, and ab initio calculations in an attempt to define the roles that the two vicinal fluorine atoms play in the puckering preferences of the fu... |
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Excited state characteristics of 6-azauracil in acetonitrile: drastically different relaxation mechanism from uracil.
J. Phys. Chem. A 112(51) , 13308-15, (2008) Excited-state dynamics of 6-azauracil (6-AU) and sensitized singlet oxygen formation in acetonitrile solution with UV irradiation were investigated for the first time. In the transient absorption measurement, the 248 nm laser photolysis gave a relatively inte... |
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Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methods.
J. Med. Chem. 53(7) , 2709-18, (2010) We recently described a set of drug-like molecules obtained from an in silico screen that stabilize mutant superoxide dismutase-1 (SOD-1) linked to familial amyotrophic lateral sclerosis (ALS) against unfolding and aggregation but exhibited poor binding speci... |
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Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7receptor antagonists leading to the discovery of the clinical candidate CE-224,535
Bioorg. Med. Chem. Lett. 21(12) , 3708-11, (2011) High throughput screening (HTS) of our compound file provided an attractive lead compound with modest P2X(7) receptor antagonist potency and high selectivity against a panel of receptors and channels, but also with high human plasma protein binding and a pred... |
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Genomewide recruitment analysis of Rpb4, a subunit of polymerase II in Saccharomyces cerevisiae, reveals its involvement in transcription elongation.
Eukaryotic Cell 7(6) , 1009-18, (2008) The Rpb4/Rpb7 subcomplex of yeast RNA polymerase II (Pol II) has counterparts in all multisubunit RNA polymerases from archaebacteria to higher eukaryotes. The Rpb4/7 subcomplex in Saccharomyces cerevisiae is unique in that it easily dissociates from the core... |