盐酸布比卡因

J. Immunol. 193(11) , 5525-33, (2014)

The developmental pathways of regulatory T cells (T(reg)) generation in the thymus are not fully understood. In this study, we reconstituted thymic development of Zap70-deficient thymocytes with a tetracycline-inducible Zap70 transgene to allow temporal disse...

Eur. J. Drug Metab. Pharmacokinet. 39(4) , 293-9, (2014)

The hydrophobic amino acyl amide-linked local anesthetics (e.g., lidocaine and bupivacaine) impose potent cardiac toxicity and direct mitochondrial dysfunction. To investigate these adverse events, an in vitro system was employed to measure their effects on O...

Psychopharmacol. Ser. 232(3) , 509-17, (2015)

Repeated exposure to psychostimulants that either increase dopamine (DA) release or target N-methyl-D-aspartate (NMDA) receptors can induce behavioural sensitisation, a phenomenon that may be important for the processes of addiction and even psychosis. A crit...

Arch. Immunol. Ther. Exp. (Warsz.) 62(6) , 483-91, (2014)

Sustained chronic inflammation induces activation of genes involved in cellular proliferation and apoptosis, thereby causing skeletal muscle degeneration. To investigate in vitro effects of isolated pentacyclic triterpenes from Eugenia punicifolia (Ep-CM) upo...

J. Surg. Res. 193(1) , 407-14, (2015)

We sough to elucidate whether purinergic P2X7 receptor is actively involved in the effects of levobupivacaine on inhibiting microglia activation.Microglia were treated with lipopolysaccharide (LPS, 50 ng/mL), LPS plus levobupivacaine (50 μM), or LPS plus levo...

Arch. Gynecol. Obstet. 290(1) , 47-52, (2014)

Pain after cesarean delivery is a leading cause of chronic pain and there are many attempts to reduce it without total success. Gabapentin is effective in reducing acute and chronic pain with little experience in parturient. The purpose of this study is to co...

Br. J. Anaesth. 114(1) , 110-20, (2015)

Opioids enhance and prolong analgesia when applied as adjuvants to local anaesthetics (LAs). A possible molecular mechanism for this property is a direct inhibition of voltage-gated Na(+) channels which was reported for some opioids. Methadone is an effective...

Br. J. Anaesth. 112(4) , 622-5, (2014)

Br. J. Anaesth. 112(4) , 729-34, (2014)

The optimal dosing regimens of lipid emulsion, epinephrine, or both are not yet determined in neonates in cases of local anaesthetic systemic toxicity (LAST).Newborn piglets received levobupivacaine until cardiovascular collapse occurred. Standard cardiopulmo...

J. Pak. Med. Assoc. 64(4) , 433-6, (2014)

To determine whether the addition of 8 mg dexamethasone to axillary brachial plexus block would prolong the duration of sensory and motor block in patients undergoing hand and forearm surgery.The prospective, randomised, double-blinded study was conducted at ...