12-O-十四烷酰佛波醋酸酯-13
12-O-十四烷酰佛波醋酸酯-13结构式
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常用名 | 12-O-十四烷酰佛波醋酸酯-13 | 英文名 | 12-O-tetradecanoylphorbol-13-acetate |
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| CAS号 | 16561-29-8 | 分子量 | 616.825 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 698.1±55.0 °C at 760 mmHg | |
| 分子式 | C36H56O8 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 208.1±25.0 °C |
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Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf.
Biochem. J. 467(3) , 425-38, (2015) Constitutive activation of the extracellular-signal-regulated kinases 1 and 2 (ERK1/2) are central to regulating the proliferation and survival of many cancer cells. The current inhibitors of ERK1/2 target ATP binding or the catalytic site and are therefore l... |
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A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses.
J. Virol. 89(9) , 4918-31, (2015) The ORF45 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus-specific immediate-early tegument protein. Our previous studies have revealed its crucial roles in both early and late stages of KSHV infection. In this study, we survey... |
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DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation.
J. Immunol. 193(11) , 5660-7, (2014) Neutrophils are highly motile leukocytes that play important roles in the innate immune response to invading pathogens. Neutrophils rapidly migrate to the site of infections and kill pathogens by producing reactive oxygen species (ROS). Neutrophil chemotaxis ... |
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Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS.
J. Immunol. 194(4) , 1545-54, (2015) Rapid and robust induction of type I IFN (IFN-I) is a critical event in host antiviral innate immune response. It has been well demonstrated that cyclic GMP-AMP (cGAMP) synthase (cGAS) plays an important role in sensing cytosolic DNA and triggering STING depe... |
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Statins increase rifampin mycobactericidal effect.
Antimicrob. Agents Chemother. 58(10) , 5766-74, (2014) Mycobacterium leprae and Mycobacterium tuberculosis antimicrobial resistance has been followed with great concern during the last years, while the need for new drugs able to control leprosy and tuberculosis, mainly due to extensively drug-resistant tuberculos... |
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OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity.
Exp. Cell Res. 331(2) , 278-91, (2015) ORP3 is an R-Ras interacting oxysterol-binding protein homolog that regulates cell adhesion and is overexpressed in several cancers. We investigated here a novel function of ORP3 dependent on its targeting to both the endoplasmic reticulum (ER) and the plasma... |
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Functional characterization of zebrafish (Danio rerio) Bcl10.
PLoS ONE 10(4) , e0122365, (2015) The complexes formed by BCL10, MALT1 and specific members of the family of CARMA proteins (CBM complex), have recently focused much attention because they represent a central hub regulating activation of the transcription factor NF-κB following various cellul... |
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Dipeptidyl peptidase 9 subcellular localization and a role in cell adhesion involving focal adhesion kinase and paxillin.
Biochim. Biophys. Acta 1853(2) , 470-80, (2015) Dipeptidyl peptidase 9 (DPP9) is a ubiquitously expressed member of the DPP4 gene and protease family. Deciphering the biological functions of DPP9 and its roles in pathogenesis has implicated DPP9 in tumor biology, the immune response, apoptosis, intracellul... |
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HIV-1 Tat inhibits phagocytosis by preventing the recruitment of Cdc42 to the phagocytic cup.
Nat. Commun. 6 , 6211, (2015) Most macrophages remain uninfected in HIV-1-infected patients. Nevertheless, the phagocytic capacity of phagocytes from these patients is impaired, favouring the multiplication of opportunistic pathogens. The basis for this phagocytic defect is not known. HIV... |
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1,25-dihydroxyvitamin D3 causes ADAM10-dependent ectodomain shedding of tumor necrosis factor receptor 1 in vascular smooth muscle cells.
Mol. Pharmacol. 87(3) , 533-42, (2015) 1,25-Dihydroxyvitamin D3 (1,25D3) has a potential antiatherosclerotic effect through anti-inflammatory actions. We investigated how 1,25D3 regulates tumor necrosis factor-α (TNF-α)-induced lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) expres... |