3,4-脱氢-DL-脯氨酸
3,4-脱氢-DL-脯氨酸结构式
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常用名 | 3,4-脱氢-DL-脯氨酸 | 英文名 | L-3-Pyrroline-2-carboxylic acid |
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| CAS号 | 3395-35-5 | 分子量 | 113.115 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 279.3±40.0 °C at 760 mmHg | |
| 分子式 | C5H7NO2 | 熔点 | 245ºC (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 122.7±27.3 °C |
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Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation.
J. Biol. Chem. 279(53) , 55051-9, (2004) Three human prolyl 4-hydroxylases (P4Hs) regulate the hypoxia-inducible transcription factors (HIFs) by hydroxylating a Leu-Xaa-Xaa-Leu-Ala-Pro motif. We report here that the two leucines in the Leu-Glu-Met-Leu-Ala-Pro core motif of a 20-residue peptide corre... |
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Overexpression of decorin by rat arterial smooth muscle cells enhances contraction of type I collagen in vitro.
Arterioscler. Thromb. Vasc. Biol. 24(1) , 67-72, (2004) Overexpression of decorin reduces neointimal thickening in balloon-injured carotid arteries of rats by decreasing the volume of neointimal extracellular matrix (ECM). We examined the hypothesis that decorin regulates ECM volume by stimulating cell-mediated co... |
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Enhanced and feedback-resistant gamma-glutamyl kinase activity of an Escherichia coli transformant carrying a mutated proB gene of Streptococcus thermophilus.
FEMS Microbiol. Lett. 182(1) , 143-7, (2000) We used a PCR-based method to generate a single base pair mutation in the proB gene of Streptococcus thermophilus, which replaced an aspartic acid with a glycine residue at position 192 of the first proline biosynthetic enzyme gamma-glutamyl kinase. This was ... |
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Molecular characterization of NikD, a new flavoenzyme important in the biosynthesis of nikkomycin antibiotics.
Biochemistry 41(52) , 15795-802, (2002) Nikkomycin antibiotics are potent inhibitors of chitin synthase, effective as therapeutic antifungal agents in humans and easily degradable insecticides in agriculture. NikD is a novel flavoprotein that catalyzes the oxidation of Delta(1)- or Delta(2)-piperid... |
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Inhibitor of C1q secretion suppresses the macrophage response to lipid A for nitric oxide but not for TNF production: evidence for a role of C1q in autocrine binding of TNF.
Immunobiology 188(3) , 242-58, (1993) Studies were designed to further define the modulatory role of complement subcomponent C1q in macrophage activation by Lipid A to mediate production of TNF and cytotoxic nitric oxide (NO). Pretreatment of macrophages for 24 h with 2.5 mM 3,4,dehydro-D,L-proli... |
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Conformational preferences and cis-trans isomerization of L-3,4-dehydroproline residue.
Biopolymers 92(5) , 387-98, (2009) The conformational study of N-acetyl-N'-methylamide of L-3,4-dehydroproline (Ac-Dhp-NHMe, the Dhp dipeptide) is carried out using hybrid density functional methods with the self-consistent reaction field method in the gas phase and in solution (chloroform and... |
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Oxidation of 3,4-dehydro-D-proline and other D-amino acid analogues by D-alanine dehydrogenase from Escherichia coli.
FEMS Microbiol. Lett. 238 , 383-389, (2004) 3,4-Dehydro-DL-proline is a toxic analogue of L-proline which has been useful in studying the uptake and metabolism of this key amino acid. When membrane fractions from Escherichia coli strain UMM5 (putA1::Tn5 proC24) lacking both L-proline dehydrogenase and ... |
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Alternative methods to limit extracellular bacterial activity for enumeration of intracellular bacteria.
J. Microbiol. Methods 64(1) , 17-26, (2006) The gentamicin survival assay, a method routinely used to estimate bacterial infection of eukaryotic host cells, depends on the presumed limited penetration of gentamicin across the eukaryotic cell membrane. However, some studies have suggested that gentamici... |
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Purification, characterization, and crystallization of human pyrroline-5-carboxylate reductase.
Protein Expr. Purif. 49(1) , 83-7, (2006) Pyrroline-5-carboxylate reductase (P5CR) catalyzes the reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline with concomitant oxidation of NAD(P)H to NAD(P)(+). The enzymatic cycle between P5C and proline is very important in many physiological and pat... |
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Complement subcomponent C1q modulation of TNF-alpha binding to L929 cells for enhanced TNF-mediated cytotoxicity.
Scand. J. Immunol. 44(2) , 101-7, (1996) Complement subcomponent C1q has been recently implicated in the modulation of autocrine binding of TNF-alpha to murine macrophages for induction of nitric oxide synthase. In the present study, the putative role of C1q in increasing TNF-alpha binding to L929 c... |