NKH 477(达福尔考辛)
NKH 477(达福尔考辛)结构式
|
常用名 | NKH 477(达福尔考辛) | 英文名 | NKH477 |
|---|---|---|---|---|
| CAS号 | 138605-00-2 | 分子量 | 546.093 | |
| 密度 | N/A | 沸点 | 571.4ºC at 760mmHg | |
| 分子式 | C27H44ClNO8 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 176ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
|
Analysis of compartmentalized cAMP: a method to compare signals from differently targeted FRET reporters.
Methods Mol. Biol. 1071 , 59-71, (2014) Förster resonance energy transfer (FRET)-based reporters are important tools to study the spatiotemporal compartmentalization of cyclic adenosine monophosphate (cAMP) in living cells. To increase the spatial resolution of cAMP detection, new reporters with sp... |
|
|
Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach.
J. Mol. Cell Biol. 5(5) , 354-5, (2013) Induced pluripotent stem cells (iPSCs) could be generated by a single gene Oct4 and chemical compounds, in which exogenous expression of Oct4 was indispensable for reprogramming. Recent advances in chemical-mediated cellular reprogramming suggest that small m... |
|
|
Activation of cAMP signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice.
Endocrinology 155(6) , 2122-32, (2014) p21-activated protein kinase-1 (Pak1) plays a role in insulin secretion and glucagon-like peptide-1 (GLP-1) production. Pak1(-/-) mice were found to carry a defect in ip pyruvate tolerance test (IPPTT), leading us to speculate whether Pak1 represses hepatic g... |
|
|
An evaluation of prophylactic treatments to prevent post traumatic joint stiffness.
J. Orthop. Res. 32(11) , 1520-4, (2014) Arthrofibrosis is a major obstacle to restoring joint function after trauma. The objective of this study was to evaluate montelukast, forskolin, and triamcinolone as possible means of prophylaxis against the formation of arthrofibrosis. Forty-eight rats under... |
|
|
Nuclear distribution of claudin-2 increases cell proliferation in human lung adenocarcinoma cells.
Biochim. Biophys. Acta 1843(9) , 2079-88, (2014) Claudin-2 is expressed in human lung adenocarcinoma tissue and cell lines, although it is absent in normal lung tissue. However, the role of claudin-2 in cell proliferation and the regulatory mechanism of intracellular distribution remain undefined. Prolifera... |
|
|
Increase in cellular cyclic AMP concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis.
Mol. Pharmacol. 84(6) , 787-93, (2013) Tissue fibrosis is characterized by excessive production, deposition, and contraction of the extracellular matrix (ECM). The second messenger cAMP has antifibrotic effects in fibroblasts from several tissues, including cardiac fibroblasts (CFs). Increased cel... |
|
|
Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors.
J. Biol. Chem. 288(45) , 32475-89, (2013) G protein-coupled receptors mediate responses to a myriad of ligands, some of which regulate adipocyte differentiation and metabolism. The sweet taste receptors T1R2 and T1R3 are G protein-coupled receptors that function as carbohydrate sensors in taste buds,... |
|
|
Cholesterol sulfate and cholesterol sulfotransferase inhibit gluconeogenesis by targeting hepatocyte nuclear factor 4α.
Mol. Cell. Biol. 34(3) , 485-97, (2014) Sulfotransferase (SULT)-mediated sulfation represents a critical mechanism in regulating the chemical and functional homeostasis of endogenous and exogenous molecules. The cholesterol sulfotransferase SULT2B1b catalyzes the sulfoconjugation of cholesterol to ... |
|
|
A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: Role of amyloid beta.
Ann. Neurol. 75(4) , 602-7, (2014) Cyclic adenosine monophosphate (cAMP) regulates long-term potentiation (LTP) and ameliorates memory in healthy and diseased brain. Increasing evidence shows that, under physiological conditions, low concentrations of amyloid β (Aβ) are necessary for LTP expre... |
|
|
Deletion of N-myc downstream-regulated gene 2 attenuates reactive astrogliosis and inflammatory response in a mouse model of cortical stab injury.
J. Neurochem. 130(3) , 374-87, (2014) N-myc downstream-regulated gene 2 (Ndrg2) is a differentiation- and stress-associated molecule predominantly expressed in astrocytes in the CNS. In this study, we examined the expression and the role of Ndrg2 after cortical stab injury. We observed that Ndrg2... |