盐酸司来吉兰
盐酸司来吉兰结构式
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常用名 | 盐酸司来吉兰 | 英文名 | Selegiline HCl |
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| CAS号 | 14611-52-0 | 分子量 | 223.742 | |
| 密度 | 0.954g/cm3 | 沸点 | 272.5ºC at 760mmHg | |
| 分子式 | C13H18ClN | 熔点 | 141-142ºC | |
| MSDS | 中文版 美版 | 闪点 | 108.4ºC |
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Flavonoids from Sideritis Species: Human Monoamine Oxidase (hMAO) Inhibitory Activities, Molecular Docking Studies and Crystal Structure of Xanthomicrol.
Molecules 20 , 7454-73, (2015) The inhibitory effects of flavonoids on monoamine oxidases (MAOs) have attracted great interest since alterations in monoaminergic transmission are reported to be related to neurodegenerative diseases such as Parkinson's and Alzheimer's diseases and psychiatr... |
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[Liver monoamine oxidase activity of the lamprey Lampetra fluviatilis. the substrate-inhibitory specificity].
Zh. Evol. Biokhim. Fiziol. 49(1) , 39-43, (2013) Based on data of substrate-inhibitory analysis with use of specific inhibitors--deprenyl, chlorgi-lin--and specific substrates--serotonin, noradrenalin, benzylamine, beta-phenylethylamine, and N-methylhistamine--a suggestion is put forward about the possible ... |
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Modulations of brain amines and dopaminergic behavior by a novel, reversible and selective MAO-B inhibitor.
Brain Res. 1470 , 45-51, (2012) Monoamine oxidase (MAO) B is a validated target for many neurodegenerative diseases. Recently we have reported a few pyrazolines as reversible and selective MAO-B inhibitors. Amongst them, we have selected the most potent analog, NP-9 (Ki=0.31 nM; selectivity... |
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Rasagiline and selegiline, inhibitors of type B monoamine oxidase, induce type A monoamine oxidase in human SH-SY5Y cells.
J. Neural Transm. Gen. Sect. 120(3) , 435-44, (2013) Type B monoamine oxidase (MAO-B) is proposed to be involved in the pathogenesis of neurodegenerative disorders, such as Parkinson's disease, through oxidative stress and synthesis of neurotoxins. MAO-B inhibitors, rasagiline and selegiline [(-)deprenyl], prot... |
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''70th Birthday Professor Riederer'' induction of glial cell line-derived and brain-derived neurotrophic factors by rasagiline and (-)deprenyl: a way to a disease-modifying therapy?
J. Neural Transm. Gen. Sect. 120(1) , 83-9, (2013) Neuroprotection has been proposed in neurodegenerative disorders, such as Parkinson's and Alzheimer's diseases, to delay or halt disease progression or reverse neuronal deterioration. The inhibitors of type B monoamine oxidase (MAO), rasagiline and (-)depreny... |
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Bacopa monnieri and L-deprenyl differentially enhance the activities of antioxidant enzymes and the expression of tyrosine hydroxylase and nerve growth factor via ERK 1/2 and NF-κB pathways in the spleen of female wistar rats.
Neurochem. Res. 38(1) , 141-52, (2013) Aging is characterized by development of diseases and cancer due to loss of central and peripheral neuroendocrine-immune responses. Free radicals exert deleterious effects on neural-immune functions in the brain, heart, and lymphoid organs and thus, affecting... |
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Involvement of monoamine oxidase B on models of postoperative and neuropathic pain in mice.
Eur. J. Pharmacol. 690(1-3) , 107-14, (2012) In this study we assessed the involvement of monoamine oxidase B (MAO-B), a key enzyme implicated in monoamine metabolism, on postoperative (plantar incision) and neuropathic (partial sciatic nerve ligation) pain models in mice. Paw incision submitted mice sh... |
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AIRE-induced apoptosis is associated with nuclear translocation of stress sensor protein GAPDH
Biochem. Biophys. Res. Commun. 423(1) , 32-7, (2012) Highlights ► AIRE induces apoptosis in epithelial cells. ► CARD domain of AIRE is sufficient for apoptosis induction. ► AIRE induced apoptosis involves GAPDH translocation to the nuclei. ► Deprenyl inhibits AIRE induced apoptosis. |
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Inhibition of bupropion metabolism by selegiline: mechanism-based inactivation of human CYP2B6 and characterization of glutathione and peptide adducts.
Drug Metab. Dispos. 40(12) , 2256-66, (2012) Selegiline, the R-enantiomer of deprenyl, is used in the treatment of Parkinson's disease. Bupropion, an antidepressant, often used to treat patients in conjunction with selegiline, is metabolized primarily by CYP2B6. The effect of selegiline on the enzymatic... |
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Selegiline (deprenyl) decreases calbindin-D28k expression in cortical neurons of rats socially deprived during the post-weaning period.
Int. J. Dev. Neurosci. 31(2) , 145-9, (2013) Preclinical studies indicate that selegiline (deprenyl), frequently used in some neurodegenerative diseases, exert protective effects on central nervous system neurons of individuals exposed to social isolation (SI). Furthermore, it has been suggested that SI... |