氧化震颤素M

Neurosci. Lett. 593 , 129-33, (2015)

Our previous investigations have revealed that cerebellar cholinergic innervation is involved in cardiovascular regulation. This study was performed to examine the effects of the muscarinic cholinergic receptor (mAChR) in the cerebellar cortex on blood pressu...

J. Neurosci. 35(8) , 3676-88, (2015)

Therapeutic repair of myelin disorders may be limited by the relatively slow rate of human oligodendrocyte differentiation. To identify appropriate pharmacological targets with which to accelerate differentiation of human oligodendrocyte progenitors (hOPCs) d...

Naunyn Schmiedebergs Arch. Pharmacol. 380(4) , 327-35, (2009)

We explored whether the M(2) muscarinic receptor in the guinea pig ileum elicits a highly potent, direct-contractile response, like that from the M(3) muscarinic receptor knockout mouse. First, we characterized the irreversible receptor-blocking activity of 4...

Biol. Pharm. Bull. 33(4) , 653-8, (2010)

The present study was undertaken to examine whether distigmine, a therapeutic agent used to treat detrusor underactivity, binds directly to muscarinic and nicotinic receptors. We used radioreceptor binding assays and compared the effects of distigmine with th...

Acta Biochim. Biophys. Sin. (Shanghai) 44(6) , 544-9, (2012)

Neurotransmitters and hormones regulate Ca(V)2.2 channels through a voltage-independent pathway which is not well understood. It has been suggested that this voltage-independent inhibition is constant at all membrane voltages. However, changes in the percent ...

Neurosci. Lett. 439(1) , 79-83, (2008)

In this study, we have assessed the effects of muscarinic receptor activation on neural activity in the telencephalon of the zebrafish. Electrically evoked field potentials via the stimulation of the posterior dorsal telencephalon were recorded in the anterio...

Mol. Pharmacol. 86(1) , 106-15, (2014)

The M(4) receptor is a compelling therapeutic target, as this receptor modulates neural circuits dysregulated in schizophrenia, and there is clinical evidence that muscarinic agonists possess both antipsychotic and procognitive efficacy. Recent efforts have s...

Mol. Pharmacol. 32 , 100, (1987)

We compared the binding characteristics of muscarinic receptors labeled by [3H]oxotremorine-M ([3H]oxo-M) in homogenates of brain cortex and heart from rat. In both tissues [3H]oxo-M bound, with the same KD (6.5 nM), to a fraction of the receptors labeled by ...

J. Auton. Pharmacol. 19 , 77, (1999)

A protocol for predicting full agonist, partial agonist, and antagonist profiles of compounds with M2 muscarinic cholinergic receptor activity was developed using radioligand binding assay techniques with [3H]-N-methyl scopolamine (NMS) and [3H]-Oxotremorine-...

Behav. Brain Res. 281 , 86-95, (2015)

Disorders characterized by disturbed cholinergic signaling, such as schizophrenia, exhibit impaired performance on measures of real-world cost/benefit decision-making. Whether the cholinergic system contributes to the choice deficits observed is currently unk...