2-羟基雌三醇
2-羟基雌三醇结构式
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常用名 | 2-羟基雌三醇 | 英文名 | 2-Hydroxyestriol |
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| CAS号 | 1232-80-0 | 分子量 | 304.38100 | |
| 密度 | 1.334 g/cm3 | 沸点 | 504.6ºC at 760 mmHg | |
| 分子式 | C18H24O4 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 238.4ºC | |
| 符号 |
GHS08 |
信号词 | Warning |
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Simultaneous perfusion of [4-14C]oestriol and [6,9-3H2]oestriol 16 alpha-monoglucuronide through the isolated rat liver. II. Kinetic aspects.
Acta Endocrinol. 100(2) , 274-8, (1982) The uptake of [4-14C]oestriol by the isolated perfused rat liver is 3.8 times faster as compared to that of simultaneously perfused [6,9-3H2]oestriol 16 alpha-monoglucuronide. During perfusion the concentration of both radioactive oestrogens decreased exponen... |
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Comparison of metabolic ratios of urinary estrogens between benign and malignant thyroid tumors in postmenopausal women.
BMC Clin. Pathol. 13 , 25, (2014) Estrogen metabolism may be associated with the pathophysiological development of papillary thyroid carcinoma (PTC).To evaluate the differential estrogen metabolism between benign and malignant PTCs, estrogen profiling by gas chromatography-mass spectrometry w... |
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Urinary hydroxyestrogens and breast cancer risk among postmenopausal women: a prospective study.
Cancer Epidemiol. Biomarkers Prev. 14(9) , 2137-42, (2005) It has been suggested that a low level of the 2-hydroxyestrogen metabolites (2-OHE) and a high level of 16alpha-hydroxyestrone (16alpha-OHE1) are associated with an enhanced risk of breast cancer. We examined the association between the metabolite levels and ... |
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Novel and potent biological antioxidants on membrane phospholipid peroxidation: 2-hydroxy estrone and 2-hydroxy estradiol.
Biochem. Biophys. Res. Commun. 142(3) , 919-24, (1987) Catechol estrogens, 2-hydroxy estrone, 2-hydroxy estradiol and 2-hydroxy estriol, were tested as possible antioxidants of phospholipid peroxidation induced by Fe3+-ADP-adriamycin, using phospholipid liposomes as lipid source and alpha-tocopherol or other ster... |
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Synthesis of 2-hydroxyestriol monoglucuronides and monosulfates.
Steroids 55(3) , 128-32, (1990) The ring A monoglucuronides and monosulfates of 2-hydroxyestriol were synthesized from 2-hydroxyestriol 16,17-diacetate by means of the Koenigs-Knorr reaction with methyl alpha-acetobromoglucuronate and sulfation with sulfur trioxide-pyridine complex, respect... |
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Effect of catechol estrogens and estriol on the induction of uterine peroxidase.
J. Steroid Biochem. 13(6) , 681-3, (1980)
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Multiplicity of in vitro glucuronidation of 2-hydroxyestriol.
J. Steroid Biochem. 36(5) , 501-3, (1990) In vitro glucuronidation of 2-hydroxyestriol has been investigated by means of HPLC with dual-electrode coulometric detection. When incubated with rat or dog liver microsomal preparation in the presence of UDPGA, 2-hydroxyestriol was transformed into the 2-gl... |
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Comparative properties of the catechol estrogens, I: methylation by catechol-O-methyltransferase and binding to cytosol estrogen receptors.
Steroids 36(1) , 1-11, (1980) Five catechol estrogens and two 2-methoxyestrogens were compared for their relative affinity of binding to hypothalamic, pituitary, and uterine cytosol estrogen receptors; and for the kinetics of the catechols' methylation by hepatic catechol-0-methyltransfer... |
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Catechol estrogens are more potent antioxidants than estrogens for the Cu(2+)-catalyzed oxidation of low or high density lipoprotein: antioxidative effects of steroids on lipoproteins.
Endocr. J. 41(6) , 605-11, (1994) In order to clarify the mechanism of antiatherogenic action of several steroids such as estrogens, dehydroepiandrosterone (DHEA) and dexamethasone, we investigated the effects of various steroids on the copper (Cu2+)-catalyzed oxidation of low density lipopro... |
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Treatment with an inhibitor of catechol-O-methyltransferase activity reduces preterm birth and impedes cervical resistance to stretch in pregnant rats.
Reproduction 134(6) , 831-9, (2007) Catechol-O-methyltransferase (COMT) enzyme catalyzes the methylation of the 2- or 4-hydroxyestrogens to 2- or 4-methoxyestrogens. Both the hydroxyestrogens and methoxyestrogens have been shown to block or enhance the effects of estrogen respectively. Our obje... |