O1-(7-chloro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-β-D-glucopyranuronic acid
![O1-(7-chloro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-β-D-glucopyranuronic acid结构式](https://image.chemsrc.com/caspic/164/6801-81-6.png)
O1-(7-chloro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-β-D-glucopyranuronic acid结构式
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常用名 | O1-(7-chloro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-β-D-glucopyranuronic acid | 英文名 | O1-(7-chloro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-β-D-glucopyranuronic acid |
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| CAS号 | 6801-81-6 | 分子量 | 462.83700 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C21H19ClN2O8 | 熔点 | N/A | |
| MSDS | N/A | 闪点 | 9 °C | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
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Factors and conditions affecting the glucuronidation of oxazepam.
Pharmacol. Toxicol. 73 Suppl 1 , 1-23, (1993) The aim of the present work was to investigate the impact of disease states and environmental and host factors on the glucuronidation of oxazepam. Glucuronidation represents quantitatively one of the most important metabolic conjugation pathways (phase II) in... |
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(S)oxazepam glucuronidation is inhibited by ketoprofen and other substrates of UGT2B7.
Pharmacogenetics 5(1) , 43-9, (1995) 1,4-Benzodiazepine anxiolytics such as diazepam and halazepam are converted in vivo to oxazepam, an active metabolite with a hydroxyl group at the asymmetric C3 position. D-glucuronic acid couples with the C3 hydroxyl group of oxazepam to form pharmacological... |
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Physiological modeling of drug and metabolite: disposition of oxazepam and oxazepam glucuronides in the recirculating perfused mouse liver preparation.
J. Pharmacokinet. Biopharm. 18(5) , 423-48, (1990) The disposition of tracer doses of 3H-oxazepam was studied in the recirculating perfused mouse liver preparation. 3H-Oxazepam was biotransformed primarily to the diastereomeric 3H-oxazepam glucuronides, which either effluxed into the circulation or underwent ... |
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The concentration of oxazepam and oxazepam glucuronide in oral fluid, blood and serum after controlled administration of 15 and 30 mg oxazepam.
Br. J. Clin. Pharmacol. 66(4) , 556-60, (2008) To measure and compare the concentration-time profiles of oxazepam and oxazepam glucuronide in blood, serum and oral fluid within the scope of roadside testing.Biological samples were collected from eight male subjects after ingestion of 15 or 30 mg oxazepam ... |
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The influence of diflunisal on the pharmacokinetics of oxazepam.
Br. J. Clin. Pharmacol. 20(3) , 225-34, (1985) Single dose pharmacokinetics of oxazepam, 30 mg, have been studied in six healthy male volunteers in the absence of diflunisal and during continuous treatment with diflunisal 500 mg twice daily. During diflunisal treatment, peak plasma concentration of oxazep... |
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Bioavailability and pharmacokinetics of oxazepam.
Eur. J. Clin. Pharmacol. 35(4) , 385-9, (1988) Six healthy volunteers received oxazepam 15 mg i.v. and orally at an interval of at least one week. The kinetic variables of i.v. oxazepam were: elimination half-life (t1/2 beta) 6.7 h, total clearance (CL) 1.07 ml.min-1.kg-1, volume of distribution (Vc) 0.27... |
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[Oxazepam glucuronide].
Beitr. Gerichtl. Med. 46 , 427-31, (1988)
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Effect of brussels sprouts and cabbage on drug conjugation.
Clin. Pharmacol. Ther. 35(2) , 161-9, (1984) Ten healthy subjects were fed three diets for 10 days each: a control diet, a cabbage and brussels sprouts--containing diet, and the control diet a second time. Oxazepam was taken on day 7 and acetaminophen on day 10 of each dietary regimen. The test diet sti... |
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Species-related differences in the stereoselective glucuronidation of oxazepam.
Drug Metab. Dispos. 10(6) , 605-8, (1982) The concentrations of (R)-(-)- and (S)-(+)-oxazepam glucuronides in plasma and urine of several species have been measured. The relative amounts of these diastereoisomers vary among species. Thus, in the plasma and urine of rhesus monkeys the concentrations o... |
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Quantitation of benzodiazepines in urine, serum, plasma, and meconium by LC-MS-MS.
J. Anal. Toxicol. 32(7) , 491-8, (2008) A single method for confirmation and quantitation of a panel of commonly prescribed benzodiazepines and metabolites, alpha-hydroxyalprazolam, alpha-hydroxyethylflurazepam, alpha-hydroxytriazolam, alprazolam, desalkylflurazepam, diazepam, lorazepam, midazolam,... |