10058-F4
10058-F4结构式
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常用名 | 10058-F4 | 英文名 | 10058-F4 |
|---|---|---|---|---|
| CAS号 | 403811-55-2 | 分子量 | 249.352 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 387.1±52.0 °C at 760 mmHg | |
| 分子式 | C12H11NOS2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 187.9±30.7 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Epstein-Barr virus nuclear antigen 3A protein regulates CDKN2B transcription via interaction with MIZ-1.
Nucleic Acids Res. 42(15) , 9700-16, (2014) The Epstein-Barr virus (EBV) nuclear antigen 3 family of protein is critical for the EBV-induced primary B-cell growth transformation process. Using a yeast two-hybrid screen we identified 22 novel cellular partners of the EBNA3s. Most importantly, among the ... |
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Loss of the Notch effector RBPJ promotes tumorigenesis.
J. Exp. Med. 212(1) , 37-52, (2015) Aberrant Notch activity is oncogenic in several malignancies, but it is unclear how expression or function of downstream elements in the Notch pathway affects tumor growth. Transcriptional regulation by Notch is dependent on interaction with the DNA-binding t... |
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Warburg-like Glycolysis and Lactate Shuttle in Mouse Decidua during Early Pregnancy.
J. Biol. Chem. 290 , 21280-91, (2015) Decidualization is an essential process of maternal endometrial stromal cells to support pregnancy. Although it is known that enhanced glucose influx is critical for decidualization, the underlying mechanism in regulating glucose metabolism in decidua remains... |
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Acidified bile acids increase hTERT expression via c-myc activation in human gastric cancer cells.
Oncol. Rep. 33 , 3038-44, (2015) Human telomerase reverse transcriptase (hTERT) is upregulated in most cancer cell types as well in immortalized cells. The underlying mechanism for such upregulation, however, remains largely unknown. We report here that bile acids under acidified media incre... |
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Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression.
Cancer Res. 74(10) , 2803-15, (2014) Sphingosine kinase 2 (SK2) may have utility as a prognostic marker in inflammatory diseases such as cancer in which it has been rationalized as a candidate therapeutic target. Here, we show that SK2 has an oncogenic role in acute lymphoblastic leukemia (ALL) ... |
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Loss of Runx2 sensitises osteosarcoma to chemotherapy-induced apoptosis.
Br. J. Cancer 113 , 1289-97, (2015) Osteosarcoma (OS) is the most common bone malignancy in the paediatric population, principally affecting adolescents and young adults. Minimal advancements in patient prognosis have been made over the past two decades because of the poor understanding of dise... |
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Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells.
Oncotarget 6 , 38934-51, (2015) Leukemia remains life-threatening despite remarkable advances in chemotherapy. The poor prognosis and drug resistance are challenging treatment. Novel drugs are urgently needed. Shikonin, a natural naphthoquinone, has been previously shown by us to be particu... |
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The c-MYC-ABCB5 axis plays a pivotal role in 5-fluorouracil resistance in human colon cancer cells.
J. Cell. Mol. Med. 19 , 1569-81, (2015) c-MYC overexpression is frequently observed in various cancers including colon cancer and regulates many biological activities such as aberrant cell proliferation, apoptosis, genomic instability, immortalization and drug resistance. However, the mechanism by ... |
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Arsenic trioxide sensitizes glioblastoma to a myc inhibitor.
PLoS ONE 10 , e0128288, (2015) Glioblastoma multiforme (GBM) is associated with high mortality due to infiltrative growth and recurrence. Median survival of the patients is less than 15 months, increasing requirements for new therapies. We found that both arsenic trioxide and 10058F4, an i... |
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PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation.
Nat. Commun. 6 , 7882, (2015) Most tumour cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and evade apoptosis. Intriguingly, the molecular mechanisms that link the Warburg effect with the suppression of apoptosis are not well understood. In this study, using l... |