|S|-(-)-1-Boc-2-吡咯烷甲腈结构式
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常用名 | |S|-(-)-1-Boc-2-吡咯烷甲腈 | 英文名 | (S)-tert-Butyl 2-cyanopyrrolidine-1-carboxylate |
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| CAS号 | 228244-04-0 | 分子量 | 196.246 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 307.9±35.0 °C at 760 mmHg | |
| 分子式 | C10H16N2O2 | 熔点 | 33-36ºC | |
| MSDS | 中文版 | 闪点 | 140.0±25.9 °C |
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New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(l-prolyl-pyrrolidine) amides.
J. Med. Chem. 46 , 4543, (2003) Isophthalic acid bis(l-prolyl-pyrrolidine) amide is a very potent prolyl oligopeptidase inhibitor, but it has a log P value of -0.2, which is very low for a compound targeted to the brain. Therefore, these types of compounds were further modified to improve t... |
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Constrained peptidomimetics reveal detailed geometric requirements of covalent prolyl oligopeptidase inhibitors.
J. Med. Chem. 52 , 6672-84, (2009) Prolyl oligopeptidases cleave peptides on the carboxy side of internal proline residues and their inhibition has potential in the treatment of human brain disorders. Using our docking program fitted, we have designed a series of constrained covalent inhibitor... |