苯并三氮唑-N,N,N',N'-四甲基脲六氟磷酸酯
苯并三氮唑-N,N,N',N'-四甲基脲六氟磷酸酯结构式
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常用名 | 苯并三氮唑-N,N,N',N'-四甲基脲六氟磷酸酯 | 英文名 | HBTU |
|---|---|---|---|---|
| CAS号 | 94790-37-1 | 分子量 | 379.24200 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C11H16F6N5OP | 熔点 | 200 °C (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 200°C | |
| 符号 |
GHS07, GHS08 |
信号词 | Danger |
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Quantification of plasma HIV RNA using chemically engineered peptide nucleic acids.
Nat. Commun. 5 , 5079, (2014) The remarkable stability of peptide nucleic acids (PNAs) towards enzymatic degradation makes this class of molecules ideal to develop as part of a diagnostic device. Here we report the development of chemically engineered PNAs for the quantitative detection o... |
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Polyamidoamine (PAMAM) dendrimers modified with short oligopeptides for early endosomal escape and enhanced gene delivery.
Int. J. Pharm. 492 , 233-43, (2015) Recently, non-viral vectors have become a popular research topic in the field of gene therapy. In this study, we conjugated short oligopeptides to polyamidoamine-generation 4 (PAMAM G4) to achieve higher transfection efficiency. Previous reports have shown th... |
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The uptake of trehalose glycolipids by macrophages is independent of Mincle.
ChemBioChem. 16(4) , 683-93, (2015) Trehalose glycolipids play an important role in the pathogenesis of Mycobacterium tuberculosis and are used as adjuvants for vaccines; however, much still remains unanswered about the mechanisms through which these glycolipids exert their immunomodulatory pot... |
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Sialidases as regulators of bioengineered cellular surfaces.
Glycobiology 25 , 784-91, (2015) Human sialidases (NEUs) catalyze the removal of N-acetyl neuraminic acids from the glycome of the cell and regulate a diverse repertoire of nominal cellular functions, such as cell signaling and adhesion. A greater understanding of their substrate permissivit... |
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LDL-R promoting activity of peptides derived from human PCSK9 catalytic domain (153-421): design, synthesis and biochemical evaluation.
Eur. J. Med. Chem. 92 , 890-907, (2015) High level of Low Density Lipoprotein-Cholesterol (LDL-C) in circulation in the blood is associated with an elevated risk of cardiovascular disease (CVD) and stroke. Currently the statin drugs which inhibit the enzyme HMG-CoA reductase responsible for cholest... |
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Preoperative Detection and Intraoperative Visualization of Brain Tumors for More Precise Surgery: A New Dual-Modality MRI and NIR Nanoprobe.
Small 11 , 4517-25, (2015) In clinical practice, it is difficult to identify tumor margins during brain surgery due to its inherent infiltrative character. Herein, a unique dual-modality nanoprobe (Gd-DOTA-Ag2S QDs, referred as Gd-Ag2S nanoprobe) is reported, which integrates advantage... |
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Qualitative and quantitative determination of peptides related to celiac disease in mixtures derived from different methods of simulated gastrointestinal digestion of wheat products.
Anal. Bioanal. Chem 406(19) , 4765-75, (2014) During wheat digestion, gluten-derived proteolytic resistant peptides are generated, some of them involved in celiac disease. In vitro digestion models able to mimic the peptides generated in the human gastrointestinal tract are extremely useful to assess the... |
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Design and solid phase synthesis of new DOTA conjugated (+)-biotin dimers planned to develop molecular weight-tuned avidin oligomers.
Org. Biomol. Chem. 13(13) , 3988-4001, (2015) Chemical modifications of the biotin carrier in pretargeted avidin–biotin radionuclide therapy may be of paramount importance for tuning the amount of the radioactivity delivered to cancer cells by labelled biotins. We report here the synthesis of a collectio... |
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Protease-degradable electrospun fibrous hydrogels.
Nat. Commun. 6 , 6639, (2015) Electrospun nanofibres are promising in biomedical applications to replicate features of the natural extracellular matrix (ECM). However, nearly all electrospun scaffolds are either non-degradable or degrade hydrolytically, whereas natural ECM degrades proteo... |
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Structural, nanomechanical, and computational characterization of D,L-cyclic peptide assemblies.
ACS Nano 9(3) , 3360-8, (2015) The rigid geometry and tunable chemistry of D,L-cyclic peptides makes them an intriguing building-block for the rational design of nano- and microscale hierarchically structured materials. Herein, we utilize a combination of electron microscopy, nanomechanica... |