3-甲基-2-苯基-N-((1S)-1-苯基丙基)喹啉-4-甲酰胺结构式
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常用名 | 3-甲基-2-苯基-N-((1S)-1-苯基丙基)喹啉-4-甲酰胺 | 英文名 | SB-222200 |
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| CAS号 | 174635-69-9 | 分子量 | 380.48200 | |
| 密度 | 1.142g/cm3 | 沸点 | 553.5ºC at 760 mmHg | |
| 分子式 | C26H24N2O | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 288.6ºC |
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Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist.
J. Pharmacol. Exp. Ther. 295(1) , 373-81, (2000) The pharmacological and pharmacokinetic profile of SB-222200 [(S)-(-)-N-(alpha-ethylbenzyl)-3-methyl-2-phenylquinoline-4-car boxami de], a human NK-3 receptor (hNK-3R) antagonist, was determined. SB-222200 inhibited (125)I-[MePhe(7)]neurokinin B (NKB) binding... |
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In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists.
Br. J. Pharmacol. 122 , 469-476, (1997) 1. Inhibition of NK3 receptor agonist-induced contraction in the rabbit isolated iris sphincter muscle was used to assess the in vitro functional activity of three 2-phenyl-4-quinolinecarboxamides, members of a novel class of potent and selective non-peptide ... |
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Expression of neurokinin B/NK3 receptor and kisspeptin/KISS1 receptor in human granulosa cells.
Hum. Reprod. 29(12) , 2736-46, (2014) Are neurokinin B (NKB), NK3 receptor (NK3R), kisspeptin (KISS1) and kisspeptin receptor (KISS1R) expressed in human ovarian granulosa cells?The NKB/NK3R and kisspeptin/KISS1R systems are co-expressed and functionally active in ovarian granulosa cells.The NKB/... |