3-甲基-2-苯基-N-((1S)-1-苯基丙基)喹啉-4-甲酰胺

更新时间：2025-08-26 22:49:14

3-甲基-2-苯基-N-((1S)-1-苯基丙基)喹啉-4-甲酰胺结构式	常用名	3-甲基-2-苯基-N-((1S)-1-苯基丙基)喹啉-4-甲酰胺	英文名	SB-222200
	CAS号	174635-69-9	分子量	380.48200
	密度	1.142g/cm3	沸点	553.5ºC at 760 mmHg
	分子式	C₂₆H₂₄N₂O	熔点	N/A
	MSDS	美版	闪点	288.6ºC

用途

SB 222200是可逆的竞争性人NK受体抑制剂,对hNK-3受体的Ki为4.4 nM,能透过血脑屏障。

中文名	3-甲基-2-苯基-N-((1S)-1-苯基丙基)喹啉-4-甲酰胺
英文名	3-methyl-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide
英文别名	更多

描述	SB 222200是可逆的竞争性人NK受体抑制剂,对hNK-3受体的Ki为4.4 nM,能透过血脑屏障。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经激肽受体信号通路 >> 神经信号通路 >> 神经激肽受体研究领域 >> 神经疾病
参考文献	[1]. Sarau HM, et al. Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist. J Pharmacol Exp Ther. 2000 Oct;295(1):373-81.

密度	1.142g/cm3
沸点	553.5ºC at 760 mmHg
分子式	C₂₆H₂₄N₂O
分子量	380.48200
闪点	288.6ºC
精确质量	380.18900
PSA	41.99000
LogP	6.48220
InChIKey	MQNYRKWJSMQECI-QFIPXVFZSA-N
SMILES	CCC(NC(=O)c1c(C)c(-c2ccccc2)nc2ccccc12)c1ccccc1
蒸汽压	2.7E-12mmHg at 25°C
折射率	1.633
储存条件	2-8℃

MSDS英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport

Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist.

J. Pharmacol. Exp. Ther. 295(1) , 373-81, (2000)

The pharmacological and pharmacokinetic profile of SB-222200 [(S)-(-)-N-(alpha-ethylbenzyl)-3-methyl-2-phenylquinoline-4-car boxami de], a human NK-3 receptor (hNK-3R) antagonist, was determined. SB-2...

In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists.

Br. J. Pharmacol. 122 , 469-476, (1997)

1. Inhibition of NK3 receptor agonist-induced contraction in the rabbit isolated iris sphincter muscle was used to assess the in vitro functional activity of three 2-phenyl-4-quinolinecarboxamides, me...

Expression of neurokinin B/NK3 receptor and kisspeptin/KISS1 receptor in human granulosa cells.

Hum. Reprod. 29(12) , 2736-46, (2014)

Are neurokinin B (NKB), NK3 receptor (NK3R), kisspeptin (KISS1) and kisspeptin receptor (KISS1R) expressed in human ovarian granulosa cells?The NKB/NK3R and kisspeptin/KISS1R systems are co-expressed ...

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago...
来源：The Scripps Research Institute Molecular Screening Center
靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298
来源：ChEMBL
靶标：Cyclin-dependent kinase 2
External Id：CHEMBL5062802

实验名称：Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
来源：ChEMBL
靶标：N/A
External Id：CHEMBL1266185

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
来源：NCGC
External Id：SNCA-p-activity-luciferase

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago...
来源：The Scripps Research Institute Molecular Screening Center
靶标：muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
来源：23265
External Id：IucA Pilot Assay Tocris Library

实验名称：Incucyte cell viability with HEK293T
来源：ChEMBL
靶标：HEK-293T
External Id：CHEMBL5058565

实验名称：Dicer-mediated maturation of pre-microRNA
来源：Center for Chemical Genomics, University of Michigan
靶标：N/A
External Id：TargetID_659_CEMA

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos...
来源：The Scripps Research Institute Molecular Screening Center
靶标：muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify...
来源：The Scripps Research Institute Molecular Screening Center
靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id：SIAE_INH_FP_1536_1X%INH PRUN

共265条，当前第1页，共27页