纳美芬

Minerva Med. 105(6) , 447-66, (2014)

Alcohol dependence (AD) is a major public health problem. Currently, three drugs for the treatment of AD have been approved by both the European Medicines Agency (EMA) and the Food and Drug Administration (FDA): acamprosate, disulfiram, and oral naltrexone. T...

JAMA 311(18) , 1889-900, (2014)

Alcohol use disorders cause substantial morbidity and early mortality yet remain greatly undertreated. Medications are considerably underused.To conduct a systematic review and meta-analysis of the benefits and harms of medications (US FDA-approved and others...

Life Sci. 86(15-16) , 624-30, (2010)

The current study assessed the in vivo antagonist properties of nalmefene using procedures previously used to characterize the opioid antagonists naloxone, naltrexone, 6beta-naltrexol and nalbuphine.ICR mice were used to generate antagonist dose-response curv...

Structure 19(11) , 1683-90, (2011)

Opioids that stimulate the μ-opioid receptor (MOR1) are the most frequently prescribed and effective analgesics. Here we present a structural model of MOR1. Molecular dynamics simulations show a ligand-dependent increase in the conformational flexibility of t...

Journal. of. Drugs in. Dermatology. 10(8) , 853-60, (2011)

To investigate the efficacy, safety and tolerability of topical nalmefene (SRD174), a long acting opioid antagonist for the management of pruritus associated with atopic dermatitis (AD).Double-blind, vehicle-controlled, randomized, cross-over trial.Eleven der...

Drugs Today (Barc) 50(5) , 347-55, (2014)

Nalmefene is the first available drug approved in the E.U. to reduce alcohol use in alcohol-dependent patients. Reduction in alcohol use in heavy drinkers diminishes mortality risk and socio-economic burden. Nalmefene has shown efficacy at 6 months in alcohol...

Pediatr. Emerg. Care 15(2) , 141-3, (1999)

BMJ 349 , g6054, (2014)

BMJ 348 , g1531, (2014)

Curr. Top. Behav. Neurosci. 13 , 583-609, (2013)

Here we discuss treatment strategies that are based on pharmacological interventions to reduce craving and relapse in alcohol-dependent patients. We will first provide a historical overview about relapse prevention strategies. We will then review the developm...