5-(4-氯苯基)-N-(3,5-二甲氧基苯基)-2-呋喃甲酰胺结构式
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常用名 | 5-(4-氯苯基)-N-(3,5-二甲氧基苯基)-2-呋喃甲酰胺 | 英文名 | A-803467 |
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| CAS号 | 944261-79-4 | 分子量 | 357.788 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 450.6±45.0 °C at 760 mmHg | |
| 分子式 | C19H16ClNO4 | 熔点 | 128-130?C | |
| MSDS | 中文版 美版 | 闪点 | 226.3±28.7 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
Proc. Natl. Acad. Sci. U. S. A. 104 , 8520-5, (2007) Activation of tetrodotoxin-resistant sodium channels contributes to action potential electrogenesis in neurons. Antisense oligonucleotide studies directed against Na(v)1.8 have shown that this channel contributes to experimental inflammatory and neuropathic p... |
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Painful research: identification of a small-molecule inhibitor that selectively targets Nav1.8 sodium channels.
Mol. Interv. 7 , 192-5, (2007) Voltage-gated sodium channels in nociceptive neurons are attractive targets for novel pain therapeutics. Although drugs that target voltage-gated sodium channels have proven value as pain therapeutics, the drugs that are currently available are non-specific s... |
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Functional Nav1.8 channels in intracardiac neurons: the link between SCN10A and cardiac electrophysiology.
Circ. Res. 111 , 333-43, (2012) The SCN10A gene encodes the neuronal sodium channel isoform Na(V)1.8. Several recent genome-wide association studies have linked SCN10A to PR interval and QRS duration, strongly suggesting an as-yet unknown role for Na(V)1.8 in cardiac electrophysiology.To de... |
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Aging-associated changes in motor axon voltage-gated Na(+) channel function in mice.
Neurobiol. Aging 39 , 128-39, (2016) Accumulating myelin abnormalities and conduction slowing occur in peripheral nerves during aging. In mice deficient of myelin protein P0, severe peripheral nervous system myelin damage is associated with ectopic expression of Nav1.8 voltage-gated Na(+) channe... |