2-乙酰胺基丙烯酸甲酯结构式
|
常用名 | 2-乙酰胺基丙烯酸甲酯 | 英文名 | Methyl 2-acetamidoacrylate |
|---|---|---|---|---|
| CAS号 | 35356-70-8 | 分子量 | 143.14100 | |
| 密度 | N/A | 沸点 | 104 °C8 mm Hg(lit.) | |
| 分子式 | C6H9NO3 | 熔点 | 50-52 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | >230 °F | |
| 符号 |
GHS07 |
信号词 | Warning |
|
The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro.
Biochem. Pharmacol. 70(11) , 1579-92, (2005) Ethyl pyruvate (EP) is a simple aliphatic ester derived from the endogenous metabolite, pyruvic acid. EP has been shown to decrease the expression of various pro-inflammatory mediators, including nitric oxide (NO*), tumor necrosis factor (TNF), cyclooxygenase... |
|
|
Methyl-2-acetamidoacrylate, an ethyl pyruvate analog, decreases sepsis-induced acute kidney injury in mice.
Am. J. Physiol. Renal Physiol. 295(6) , F1825-35, (2008) We tested the anti-inflammatory agent methyl-2-acetamidoacrylate (M2AA), an ethyl pyruvate analog, in a cecal ligation-and-puncture (CLP) model of sepsis in CD-1 mice. M2AA administration at the time of CLP improved survival, renal function, kidney histology,... |
|
|
Orthogonal synthesis of indolines and isoquinolines via aryne annulation.
J. Am. Chem. Soc. 130(5) , 1558-9, (2008)
|
|
|
Enantioselective synthesis of tryptophan derivatives by a tandem Friedel-Crafts conjugate addition/asymmetric protonation reaction.
J. Am. Chem. Soc. 134(11) , 5131-7, (2012) The tandem Friedel-Crafts conjugate addition/asymmetric protonation reaction between 2-substituted indoles and methyl 2-acetamidoacrylate is reported. The reaction is catalyzed by (R)-3,3'-dibromo-BINOL in the presence of stoichiometric SnCl(4), and is the fi... |
|
|
Asymmetric hydrogenation using chiral Rh complexes immobilised with a new ion-exchange strategy.
Org. Biomol. Chem. 3(8) , 1547-50, (2005) Rh diphosphine complexes using DuPhos and JosiPhos as chiral ligands have been immobilised by ion exchange into the mesoporous material MCM-41. When used as catalysts for the enantioselective hydrogenation of dimethyl itaconate and methyl-2-acetamidoacrylate,... |
|
|
Extended para-hydrogenation monitored by NMR spectroscopy.
Chem. Commun. (Camb.) 47(3) , 958-60, (2011) A system that provides a sustained hyperpolarized (1)H NMR signal in an aqueous medium is reported. The enhanced signal lasts much longer than typical (1)H T(1) values, uncovering new possibilities for implementing hyperpolarized (1)H NMR/MRI experiments or p... |
|
|
Methyl mercapturate synthesis: an efficient, convenient and simple method.
Molecules 13(10) , 2394-407, (2008) A safe and simple method for methyl S-arylmercapturate synthesis is described. Thirteen such compounds, to be used afterwards in metabolism studies, have been obtained with yields ranging from 71 to 99.6%. These compounds were obtained using a sulfa-Michael a... |
|
|
FeCl3-catalyzed conjugate addition of secondary amines, imidazole and pyrazole to methyl 2-acetamidoacrylate. Montserrat P and Pleixats R
Tetrahedron 51(30) , 8355-8362, (1995)
|
|
|
Synthesis of α-amino acid derivatives by copper(I)-catalyzed conjugate addition of grignard reagents to methyl 2-acetamidoacrylate, Cardellicchio C, et al.
Tetrahedron 26(36) , 4387-4390, (1985)
|
|
|
Thermosensitive properties of a novel poly(methyl 2-acetamidoacrylate-co-methyl acrylate) Okamura H, et al.
Eur. Polym. J. 38(4) , 639-644, (2002)
|