盐酸普罗替林结构式
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常用名 | 盐酸普罗替林 | 英文名 | Protriptyline hydrochloride |
|---|---|---|---|---|
| CAS号 | 1225-55-4 | 分子量 | 299.838 | |
| 密度 | N/A | 沸点 | 407.7ºC at 760 mmHg | |
| 分子式 | C19H22ClN | 熔点 | 169-171° | |
| MSDS | 中文版 美版 | 闪点 | 198.3ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
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In pursuit of drugs for American trypanosomiasis: evaluation of some "standards" in a mouse model.
Proc. Soc. Exp. Biol. Med. 216(3) , 424-8, (1997) Forty-nine "standard" compounds known to be useful in the treatment of other diseases were tested for their suppressive activity against the trypomastigotes of Trypanosoma cruzi-infected mice. The most active was the antidepressant protriptyline, which was al... |
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Protriptyline, chronic tension-type headaches, and weight loss in women.
Headache 37(7) , 433-6, (1997) Twenty-five women with chronic tension-type headaches were treated with protriptyline for 3 months, with attention paid to days of monthly headaches before and while taking the medication, as well as change in weight and side effects. One patient stopped the ... |
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Nocturnal respiratory failure as an indication of noninvasive ventilation in the patient with neuromuscular disease.
Respiration 64 Suppl 1 , 35-8, (1997) Patients with neuromuscular disease may suffer from nocturnal respiratory failure despite normal daytime respiratory function. The physiological reduction in muscle tone during sleep may be life-threatening in a patient with impaired muscle strength. Nocturna... |
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The carotid body in the motorneuron response to protriptyline.
Respir. Physiol. 93(1) , 41-9, (1993) Protriptyline (PRT) has been shown to preferentially stimulate upper airway inspiratory motorneurons relative to phrenic activity in hyperoxic hypercapnia in the decerebrate cat via a carotid body-independent mechanism. Since previous studies indicated that c... |
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In vitro studies of DNA damage caused by tricyclic antidepressants: a role of peroxidase in the side effects of the drugs.
Chem. Res. Toxicol. 23(9) , 1497-503, (2010) Studies show that tricyclic antidepressants prescribed for migraines, anxiety, and child enuresis have numerous adverse effects in living cells. One of the undesired outcomes observed under treatment with these drugs is DNA damage. However, the mechanisms und... |
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Hyperekplexia: report of a nonfamilial adult onset case associated with obstructive sleep apnea and abnormal brain nuclear tomography.
Sleep 17(3) , 280-3, (1994) We report the unique occurrence of hyperekplexia and obstructive sleep apnea (OSA) in a 48-year-old male. Polysomnography and multiple sleep latency testing excluded cataplexy, which can be confused with startle attacks. A new imaging finding was a nuclear to... |
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Biotransformation of protriptyline by filamentous fungi and yeasts.
Xenobiotica 29(7) , 733-46, (1999) 1. The potential of various fungi to metabolize protriptyline (an extensively used antidepressant) was studied to investigate similarities between mammalian and microbial metabolism. 2. Metabolites produced by each organism were isolated by high-pressure liqu... |
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Nonsurgical management of the obstructive sleep apnea patient.
J. Oral Maxillofac. Surg. 54(9) , 1103-8, (1996)
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Protriptyline block of the human ether-à-go-go-related gene (HERG) K+ channel.
Life Sci. 82(5-6) , 331-40, (2008) Protriptyline, a tricyclic antidepressant for psychiatric disorders, can induce prolonged QT, torsades de pointes, and sudden death. We studied the effects of protriptyline on human ether-à-go-go-related gene (HERG) channels expressed in Xenopus oocytes and H... |
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Anticholinergic delirium possibly associated with protriptyline and fluoxetine.
Ann. Pharmacother. 31(10) , 1260-1, (1997)
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