L-半胱氨酸
L-半胱氨酸结构式
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常用名 | L-半胱氨酸 | 英文名 | L-cysteine |
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| CAS号 | 52-90-4 | 分子量 | 121.158 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 293.9±35.0 °C at 760 mmHg | |
| 分子式 | C3H7NO2S | 熔点 | 220 °C (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 131.5±25.9 °C |
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Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.
Drug Des. Devel. Ther. 9 , 1555-84, (2015) Osteosarcoma (OS) is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to current therapeutics. Alisertib (ALS, MLN8237) is a selective Aurora kinase A inhibitor that displays a... |
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The unique regulation of iron-sulfur cluster biogenesis in a Gram-positive bacterium.
Proc. Natl. Acad. Sci. U. S. A. 111(22) , E2251-60, (2014) Iron-sulfur clusters function as cofactors of a wide range of proteins, with diverse molecular roles in both prokaryotic and eukaryotic cells. Dedicated machineries assemble the clusters and deliver them to the final acceptor molecules in a tightly regulated ... |
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Pharmacological inhibition of dynamin II reduces constitutive protein secretion from primary human macrophages.
PLoS ONE 9(10) , e111186, (2014) Dynamins are fission proteins that mediate endocytic and exocytic membrane events and are pharmacological therapeutic targets. These studies investigate whether dynamin II regulates constitutive protein secretion and show for the first time that pharmacologic... |
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Structural insights into the broad substrate specificity of carboxypeptidase T from Thermoactinomyces vulgaris.
FEBS J. 282(7) , 1214-24, (2015) The crystal structures of carboxypeptidase T (CpT) complexes with phenylalanine and arginine substrate analogs - benzylsuccinic acid and (2-guanidinoethylmercapto)succinic acid - were determined by the molecular replacement method at resolutions of 1.57 Å and... |
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Optimization of ultrasound assisted extraction of bioactive components from brown seaweed Ascophyllum nodosum using response surface methodology.
Ultrason. Sonochem. 23 , 308-16, (2014) The objective of this study was to investigate the effect of key extraction parameters of extraction time (5-25 min), acid concentration (0-0.06 M HCl) and ultrasound amplitude (22.8-114 μm) on yields of bioactive compounds (total phenolics, fucose and uronic... |
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L-cysteine-capped core/shell/shell quantum dot-graphene oxide nanocomposite fluorescence probe for polycyclic aromatic hydrocarbon detection.
Talanta 146 , 780-8, (2015) Environmental pollutants, such as the polycyclic aromatic hydrocarbons (PAHs), become widely distributed in the environment after emission from a range of sources, and they have potential biological effects, including toxicity and carcinogenity. In this work,... |
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Multiplexed paper analytical device for quantification of metals using distance-based detection.
Lab Chip 15 , 2808-18, (2015) Exposure to metal-containing aerosols has been linked with adverse health outcomes for almost every organ in the human body. Commercially available techniques for quantifying particulate metals are time-intensive, laborious, and expensive; often sample analys... |
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Defects in subventricular zone pigmented epithelium-derived factor niche signaling in the senescence-accelerated mouse prone-8.
FASEB J. 29 , 1480-92, (2015) We studied potential changes in the subventricular zone (SVZ) stem cell niche of the senescence-accelerated mouse prone-8 (SAM-P8) aging model. Bromodeoxyuridine (BrdU) assays with longtime survival revealed a lower number of label-retaining stem cells in the... |
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Andrographolide sodium bisulphite-induced inactivation of urease: inhibitory potency, kinetics and mechanism.
BMC Complement Altern. Med. 15 , 238, (2015) The inhibitory effect of andrographolide sodium bisulphite (ASB) on jack bean urease (JBU) and Helicobacter pylori urease (HPU) was performed to elucidate the inhibitory potency, kinetics and mechanism of inhibition in 20 mM phosphate buffer, pH 7.0, 2 mM EDT... |
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Formaldehyde Crosses the Human Placenta and Affects Human Trophoblast Differentiation and Hormonal Functions.
PLoS ONE 10 , e0133506, (2015) The chorionic villus of the human placenta is the source of specific endocrine functions and nutrient exchanges. These activities are ensured by the syncytiotrophobast (ST), which bathes in maternal blood. The ST arises and regenerates throughout pregnancy by... |