L-cysteine

Modify Date: 2024-01-02 11:25:49

L-cysteine structure	Common Name	L-cysteine
	CAS Number	52-90-4	Molecular Weight	121.158
	Density	1.3±0.1 g/cm3	Boiling Point	293.9±35.0 °C at 760 mmHg
	Molecular Formula	C₃H₇NO₂S	Melting Point	220 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	131.5±25.9 °C

Common Name	L-cysteine
CAS Number	52-90-4	Molecular Weight	121.158
Density	1.3±0.1 g/cm3	Boiling Point	293.9±35.0 °C at 760 mmHg
Molecular Formula	C₃H₇NO₂S	Melting Point	220 °C (dec.)(lit.)
MSDS	Chinese USA	Flash Point	131.5±25.9 °C

Purity		Quantity		Budget		Inquiry

Use of L-cysteine

L-Cysteine is a thiol-containing non-essential amino acid that is oxidized to form cystine.

Name	L-cysteine
Synonym	More Synonyms

Description	L-Cysteine is a thiol-containing non-essential amino acid that is oxidized to form cystine.
Related Catalog	Natural Products >> Acids and Aldehydes Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
References	[1]. McGavigan AK, et al. L-cysteine suppresses ghrelin and reduces appetite in rodents and humans. Int J Obes (Lond). 2015 Mar;39(3):447-55.

Density	1.3±0.1 g/cm3
Boiling Point	293.9±35.0 °C at 760 mmHg
Melting Point	220 °C (dec.)(lit.)
Molecular Formula	C₃H₇NO₂S
Molecular Weight	121.158
Flash Point	131.5±25.9 °C
Exact Mass	121.019745
PSA	102.12000
LogP	0.23
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.550
Water Solubility	280 g/L (25 ºC)

L-cysteine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HA1600000

CHEMICAL NAME :: Cysteine, L-

CAS REGISTRY NUMBER :: 52-90-4

LAST UPDATED :: 199710

DATA ITEMS CITED :: 31

MOLECULAR FORMULA :: C3-H7-N-O2-S

MOLECULAR WEIGHT :: 121.17

WISWESSER LINE NOTATION :: QVYZ1SH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1890 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1620 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1550 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1360 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 gm/kg/30D-C

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 308 gm/kg/26W-I

TOXIC EFFECTS :: Cardiac - other changes Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 gm/kg/30D-C

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Endocrine - other changes Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 100 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3600 mg/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - physical

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 27600 mg/kg

SEX/DURATION :: female 23 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6 gm/kg

SEX/DURATION :: male 30 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 100 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 68,351,1979 *** REVIEWS *** TOXICOLOGY REVIEW DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 3(1),14,1983 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 2 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4773 No. of Facilities: 81 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 8402 (estimated) No. of Female Employees: 7734 (estimated)

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R36/37/38
Safety Phrases	S36-S37/39-S26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	HA1600000
HS Code	2930901000

(S)-3-amino-2-o...

112839-94-8

~86%

L-cysteine

52-90-4

Literature: Arnold,L.D.; May,R.G.; Vederas,J.C. Journal of the American Chemical Society, 1988 , vol. 110, p. 2237

L-Cysteine hydr...

52-89-1

~92%

L-cysteine

52-90-4

Literature: HYPERBRANCH MEDICAL TECHNOLOGY, INC. Patent: WO2007/1926 A2, 2007 ; Location in patent: Page/Page column 257 ;

D-Cysteine

921-01-7

~77%

L-cysteine

52-90-4

Literature: Beard, Timothy M; Turner, Nicholas J Chemical communications (Cambridge, England), 2002 , # 3 p. 246 - 247

Precursor 10	Previous 1/3 Next
CAS#:112839-94-8 (S)-3-amino-2-o... CAS#:52-89-1 L-Cysteine hydr... CAS#:921-01-7 D-Cysteine CAS#:83961-81-3 2-amino-3-phena...
CAS#:2731-73-9 3-Chloro-L-alanine CAS#:56-89-3 L-Cystine CAS#:34592-47-7 L-Thioproline CAS#:1336-21-6 Aqueous ammonia
CAS#:2485-62-3 mecysteine CAS#:2544-31-2 H-Cys(pMeOBzl)-OH
DownStream 10	Previous 1/3 Next
CAS#:105099-08-9 (2R)-3-sulfanyl... CAS#:1115-65-7 L-Cysteinesulfi... CAS#:498-40-8 furoic acid CAS#:56-89-3 L-Cystine
CAS#:73243-12-6 2-amino-3-hydro... CAS#:6020-39-9 meso-cystine CAS#:105099-10-3 (2R)-2-[(1-meth... CAS#:56-88-2 L-Cystathionine
CAS#:7783-06-4 hydrogen sulfide CAS#:1708-32-3 2,5-Dihydrothiophene

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.

Drug Des. Devel. Ther. 9 , 1555-84, (2015)

Osteosarcoma (OS) is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to current therapeutics. Alisertib (ALS, MLN823...

The unique regulation of iron-sulfur cluster biogenesis in a Gram-positive bacterium.

Proc. Natl. Acad. Sci. U. S. A. 111(22) , E2251-60, (2014)

Iron-sulfur clusters function as cofactors of a wide range of proteins, with diverse molecular roles in both prokaryotic and eukaryotic cells. Dedicated machineries assemble the clusters and deliver t...

Pharmacological inhibition of dynamin II reduces constitutive protein secretion from primary human macrophages.

PLoS ONE 9(10) , e111186, (2014)

Dynamins are fission proteins that mediate endocytic and exocytic membrane events and are pharmacological therapeutic targets. These studies investigate whether dynamin II regulates constitutive prote...

Cysteine

E 920

H-Cys-OH.Hcl

CYSTEINE, L-

H-Cys-OH

L-2-Amino-3-mercaptopropionic acid

CYSH

L-Cysteine

3-mercapto-L-Alanine

L-Cys

b-Mercaptoalanine

Cys

a-Amino-b-thiolpropionic Acid

cystein

(R)-(+)-Cysteine

FEMA 3263

L-β-Mercaptoalanine

EINECS 200-158-2

α-Amino-β-thiolpropionic acid, L-

Thioserine

(+)-2-Amino-3-mercaptopropionic acid

α-Amino-β-mercaptopropanoic acid, L-

(R)-2-amino-3-mercapto-Propanoic acid

(2R)-2-amino-3-mercaptopropanoic acid

(2R)-2-amino-3-sulfanylpropanoic acid

hydrogen L-cysteinate

β-Mercaptoalanine, L-

(R)-2-Amino-3-mercaptopropionic acid

(R)-Cysteine

2-Amino-3-mercaptopropanoic acid, (R)-

MFCD00064306

Acetylcysteine Impurity 2

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China
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GL Biochem (Shanghai) Ltd.
China
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: L-cysteine
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DC Chemicals Limited
China
Product Name: L-Cysteine
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: L-Cysteine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: L-Cysteine
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Taiwan Oyi peptide Co. Ltd
China
Product Name: L-Cysteine
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Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: L-cysteine
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
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L-cysteine

Use of L-cysteine

Names

L-cysteine Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

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Synonyms