L-cysteine

Modify Date: 2024-01-02 11:25:49

L-cysteine Structure
L-cysteine structure
 Common Name L-cysteine
CAS Number 52-90-4 Molecular Weight 121.158
Density 1.3±0.1 g/cm3 Boiling Point 293.9±35.0 °C at 760 mmHg
Molecular Formula C3H7NO2S Melting Point 220 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 131.5±25.9 °C

 Use of L-cysteine


L-Cysteine is a thiol-containing non-essential amino acid that is oxidized to form cystine.

 Names

Name L-cysteine
Synonym More Synonyms

 L-cysteine Biological Activity

Description L-Cysteine is a thiol-containing non-essential amino acid that is oxidized to form cystine.
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. McGavigan AK, et al. L-cysteine suppresses ghrelin and reduces appetite in rodents and humans. Int J Obes (Lond). 2015 Mar;39(3):447-55.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 293.9±35.0 °C at 760 mmHg
Melting Point 220 °C (dec.)(lit.)
Molecular Formula C3H7NO2S
Molecular Weight 121.158
Flash Point 131.5±25.9 °C
Exact Mass 121.019745
PSA 102.12000
LogP 0.23
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.550
Water Solubility 280 g/L (25 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HA1600000
CHEMICAL NAME :
Cysteine, L-
CAS REGISTRY NUMBER :
52-90-4
LAST UPDATED :
199710
DATA ITEMS CITED :
31
MOLECULAR FORMULA :
C3-H7-N-O2-S
MOLECULAR WEIGHT :
121.17
WISWESSER LINE NOTATION :
QVYZ1SH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1890 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - other changes in urine composition
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1620 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1550 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
660 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1360 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
150 gm/kg/30D-C
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
308 gm/kg/26W-I
TOXIC EFFECTS :
Cardiac - other changes Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
90 gm/kg/30D-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Endocrine - other changes Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
100 mg/kg
SEX/DURATION :
female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3600 mg/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - physical
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
27600 mg/kg
SEX/DURATION :
female 23 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6 gm/kg
SEX/DURATION :
male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 68,351,1979 *** REVIEWS *** TOXICOLOGY REVIEW DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 3(1),14,1983 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 2 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4773 No. of Facilities: 81 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 8402 (estimated) No. of Female Employees: 7734 (estimated)

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R36/37/38
Safety Phrases S36-S37/39-S26
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS HA1600000
HS Code 2930901000

 Synthetic Route

 Customs

HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

Cysteine
E 920
H-Cys-OH.Hcl
CYSTEINE, L-
H-Cys-OH
L-2-Amino-3-mercaptopropionic acid
CYSH
L-Cysteine
3-mercapto-L-Alanine
L-Cys
b-Mercaptoalanine
Cys
a-Amino-b-thiolpropionic Acid
cystein
(R)-(+)-Cysteine
FEMA 3263
L-β-Mercaptoalanine
EINECS 200-158-2
α-Amino-β-thiolpropionic acid, L-
Thioserine
(+)-2-Amino-3-mercaptopropionic acid
α-Amino-β-mercaptopropanoic acid, L-
(R)-2-amino-3-mercapto-Propanoic acid
(2R)-2-amino-3-mercaptopropanoic acid
(2R)-2-amino-3-sulfanylpropanoic acid
hydrogen L-cysteinate
β-Mercaptoalanine, L-
(R)-2-Amino-3-mercaptopropionic acid
(R)-Cysteine
2-Amino-3-mercaptopropanoic acid, (R)-
MFCD00064306
Acetylcysteine Impurity 2
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