盐酸喹那普利

Acta Pol. Pharm. 70(6) , 967-76, (2013)

Two methods, spectrophotometric and chromatographic-densitometric ones, were developed for determination of losartan potassium, quinapril hydrochloride and hydrochlorothiazide in pharmaceutical preparations. Spectrophotometric method involved derivative spect...

Drug Metab. Dispos. 42(9) , 1522-31, (2014)

Hydrolysis plays an important role in metabolic activation of prodrugs. In the current study, species and in vitro system differences in hepatic and extrahepatic hydrolysis were investigated for 11 prodrugs. Ten prodrugs in the data set are predominantly hydr...

J. Cardiovasc. Pharmacol. Ther. 17(2) , 139-45, (2012)

We sought to determine whether a combination of angiotensin-converting enzyme inhibitors (ACEIs) and the nutraceutical α-lipoic acid (ALA) regulates blood pressure, endothelial function, and proteinuria in diabetic patients with Stage I hypertension.A total o...

Nephrol. Dial. Transplant. 24(12) , 3640-51, (2009)

Blockade of the renin-angiotensin-aldosterone system (RAAS) does not completely prevent progression of renal disease. Mineralocorticoid receptor blockade provides additional renoprotection over ACE-inhibition monotherapy. We examined the mechanisms underlying...

Am. J. Hypertens. 23(11) , 1179-82, (2010)

Angiotensin-converting enzyme (ACE) inhibitors differ in their lipophilic/hydrophilic index that determines their tissue bioavailability and affinity to ACE, which may result in major differences in the degree of blockade of cardiac ACE. We evaluated the hypo...

Am. J. Cardiol. 108(2) , 294-301, (2011)

The renin-angiotensin system is an important mediator of tumor progression and metastasis. A recent meta-analysis of randomized controlled trials reported an increased risk of cancer with angiotensin receptor blockers. It is unknown whether angiotensin-conver...

J. Pharmacol. Exp. Ther. 341(3) , 626-33, (2012)

Indoxyl sulfate (IS) is an organic anion uremic toxin that accumulates in patients with chronic kidney disease (CKD). The aims of this study were to examine the kinetic profiles of IS in humans at a steady state after multiple doses of L-Trp, a precursor of I...

Am. J. Cardiol. 105(1) , 54-8, (2010)

Angiotensin-converting enzyme inhibitors have been reported to inhibit in-stent restenosis. To assess the effect of angiotensin-converting enzyme inhibition on in-stent restenosis and its relation to apoptosis, 86 patients with chronic coronary artery disease...

Thromb. Res. 130(1) , 99-103, (2012)

We sought to determine plasma fibrin clot properties in hypertensive subjects and to evaluate potential effects of antihypertensive therapy on these parameters.Sixty-one patients (30 men, 31 women) with essential arterial hypertension stage 1 or 2 (aged 46.6 ...

J. Pharm. Sci. 99(6) , 2786-99, (2010)

To determine the surface acidity and stability profiles of quinapril hydrochloride (QHCl) coground with silicates, solid-state equivalent pH (pHeq) of amorphous samples was measured by diffuse reflectance spectroscopy using pH indicator probes. Calibration cu...