二乙烯三胺五乙酸
二乙烯三胺五乙酸结构式
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常用名 | 二乙烯三胺五乙酸 | 英文名 | Diethylenetriaminepentaacetic acid |
|---|---|---|---|---|
| CAS号 | 67-43-6 | 分子量 | 393.346 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 721.1±60.0 °C at 760 mmHg | |
| 分子式 | C14H23N3O10 | 熔点 | 219-220 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 389.9±32.9 °C | |
| 符号 |
GHS07, GHS08 |
信号词 | Warning |
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Investigation of a Degradant in a Biologics Formulation Buffer Containing L-Histidine.
Pharm. Res. 32 , 2625-35, (2015) An unknown UV 280 nm absorbing peak was observed by SEC for protein stability samples formulated in L-histidine during a stress stability study. Understanding the source would enhance the confidence in the SEC results. We identified the unknown peak, studied ... |
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Effect of co-ligands on chemical and biological properties of (99m)Tc(III) complexes [(99m)Tc(L)(CDO)(CDOH)2BMe] (L=Cl, F, SCN and N3; CDOH2=cyclohexanedione dioxime).
Nucl. Med. Biol. 41(10) , 813-24, (2014) (99m)Tc-Teboroxime ([(99m)TcCl(CDO)(CDOH)2BMe]) is a member of the BATO (boronic acid adducts of technetium dioximes) class of (99m)Tc(III) complexes. This study sought to explore the impact of co-ligands on solution stability, heart uptake and myocardial ret... |
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Dicarbonyl Induced Structural Perturbations Make Histone H1 Highly Immunogenic and Generate an Auto-Immune Response in Cancer.
PLoS ONE 10 , e0136197, (2015) Increased oxidative stress under hyperglycemic conditions, through the interaction of AGEs with RAGE receptors and via activation of interleukin mediated transcription signalling, has been reported in cancer. Proteins modifications are being explored for thei... |
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A family of cationic polyamides for in vitro and in vivo gene transfection.
Acta Biomater. 22 , 120-30, (2015) The purpose of this study is to develop biodegradable cationic polyamides for non-viral gene delivery and elucidate their structural effects on gene transfection activity. To this end, a group of novel cationic polyamides were synthesized by polycondensation ... |
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Different mechanisms are involved in oxidative DNA damage and genotoxicity induction by ZnO and TiO2 nanoparticles in human colon carcinoma cells.
Toxicol. In Vitro 29 , 1503-12, (2015) In this work we investigated the genotoxicity of zinc oxide and titanium dioxide nanoparticles (ZnO NPs; TiO2 NPs) induced by oxidative stress on human colon carcinoma cells (Caco-2 cells). We measured free radical production in acellular conditions by Electr... |
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Toward Repositioning Niclosamide for Antivirulence Therapy of Pseudomonas aeruginosa Lung Infections: Development of Inhalable Formulations through Nanosuspension Technology.
Mol. Pharm. 12 , 2604-17, (2015) Inhaled antivirulence drugs are currently considered a promising therapeutic option to treat Pseudomonas aeruginosa lung infections in cystic fibrosis (CF). We have recently shown that the anthelmintic drug niclosamide (NCL) has strong quorum sensing (QS) inh... |
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Validation of 64Cu-DOTA-rituximab injection preparation under good manufacturing practices: a PET tracer for imaging of B-cell non-Hodgkin lymphoma.
Mol. Imaging 14 , (2015) Manufacturing of 64Cu-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA)-rituximab injection under good manufacturing practices (GMP) was validated for imaging of patients with CD20+ B-cell non-Hodgkin lymphoma. Rituximab was purified by siz... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Effective photothermal chemotherapy with docetaxel-loaded gold nanospheres in advanced prostate cancer.
J. Drug Target. 23 , 568-76, (2015) Multifunctional gold nanospheres (MGNs)-loaded with docetaxel (MGN@DTX) were prepared and evaluated for therapeutic efficacy in nude mice bearing human prostate cancer xenografts.MGNs were prepared from PEGylated hollow gold nanospheres (HGNs) coated with fol... |
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Effects of regular consumption of vitamin C-rich or polyphenol-rich apple juice on cardiometabolic markers in healthy adults: a randomized crossover trial.
Eur. J. Nutr. 53(8) , 1645-57, (2014) The aim of the present study was to investigate the effects of the consumption of two cloudy apple juices with different polyphenol and vitamin C contents on antioxidant status, cardiometabolic and inflammation markers in healthy young adults.Twenty subjects,... |