丙炔酸
一般危化品
丙炔酸结构式
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常用名 | 丙炔酸 | 英文名 | Propiolic acidd |
|---|---|---|---|---|
| CAS号 | 471-25-0 | 分子量 | 70.047 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 139.7±0.0 °C at 760 mmHg | |
| 分子式 | C3H2O2 | 熔点 | 16-18 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 58.9±0.0 °C | |
| 符号 |
GHS02, GHS05, GHS06 |
信号词 | Danger |
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Identification of the toxic trigger in mushroom poisoning.
Nat. Chem. Biol. 5 , 465-7, (2009) We have isolated the small, highly strained carboxylic acid cycloprop-2-ene carboxylic acid from the Asian toxic mushroom Russula subnigricans. This compound is responsible for fatal rhabdomyolysis, a new type of mushroom poisoning that is indicated by an inc... |
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Hierarchically functionalized magnetic core/multishell particles and their postsynthetic conversion to polymer capsules.
ACS Nano 9 , 4219-26, (2015) The controlled synthesis of hierarchically functionalized core/multishell particles is highly desirable for applications in medicine, catalysis, and separation. Here, we describe the synthesis of hierarchically structured metal-organic framework multishells a... |
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Development of a tailor-made bis(oxazolidine)pyridine-metal catalyst for the [3+2] cycloaddition of azomethine imines with propiolates.
Chem. Commun. (Camb.) 49(71) , 7776-8, (2013) A series of bis(oxazolidine)pyridine ligands (the PyBodines) were newly designed and synthesized for the development of a highly efficient, tailor-made catalyst for the [3+2] cycloaddition of azomethine imines with propiolates. The PyBodine(l-Ala)-Cu(OAc)2 ca... |
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Copper-catalyzed oxidative decarboxylative couplings of sulfoximines and aryl propiolic acids.
Org. Lett. 15(24) , 6155-7, (2013) A method has been developed for the preparation of N-alkynylated sulfoximines involving the copper-catalyzed decarboxylative coupling of sulfoximines with aryl propiolic acids. A range of substituents on both the sulfoximidoyl moiety and the aryl group of the... |
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Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors.
J. Med. Chem. 52 , 5496-504, (2009) NAD(+)-dependent sirtuin deacetylases have emerged as potential therapeutic targets for treatment of human illnesses such as cancer, metabolic, cardiovascular, and neurodegenerative diseases. The benefits of sirtuin modulation by small molecules have been dem... |
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Discovery and preclinical evaluation of a novel class of cytotoxic propynoic acid carbamoyl methyl amides (PACMAs).
J. Med. Chem. 54 , 2902-14, (2011) Herein, we discovered a series of propynoic acid carbamoyl methyl-amides (PACMAs) with potent cytotoxicity against a panel of cancer cell lines. These compounds interrupted cell cycle progression at low micromolar concentrations and induced early and late sta... |
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Highly stereoselective synthesis of (Z)- and (E)-chloro-substituted-α-methylene-γ-butyrolactone by possibly controlling cis- and trans-chloropalladation.
Mol. Divers. 17(1) , 1-7, (2013) A palladium-catalyzed selective synthesis of cis- or trans-chloro-substituted-α-methylene-γ-butyrolactones from single substrate (propiolic acid) has been realized by controlling cis- or trans-chloropalladation. This method is highly effective for building C-... |
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Asymmetric alkynylation of aldehydes with propiolates without high reagent loading and any additives.
Org. Biomol. Chem. 9(12) , 4425-8, (2011) The asymmetric alkynylation of aliphatic and aromatic aldehydes with propiolates was mediated by dialkylzinc and a novel prolinol catalyst without high reagent loading and any additives, such as Ti(Oi-Pr)(4), to give the corresponding γ-hydroxy-α,β-acetylenic... |
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Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment.
Proc. Natl. Acad. Sci. U. S. A. 109(40) , 16348-53, (2012) Protein disulfide isomerase (PDI), an endoplasmic reticulum chaperone protein, catalyzes disulfide bond breakage, formation, and rearrangement. The effect of PDI inhibition on ovarian cancer progression is not yet clear, and there is a need for potent, select... |
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Catalytic addition of alkyne C-H, amine N-H, and phosphine P-H bonds to carbodiimides: an efficient route to propiolamidines, guanidines, and phosphaguanidines.
Org. Biomol. Chem. 6(10) , 1720-30, (2008) Various metal complexes (e.g., lanthanides, early transition metals, and alkali metals) can serve as catalyst precursors for the catalytic addition of alkyne C-H, amine N-H, and phosphine P-H bonds to carbodiimides, to give a new family of propiolamidines, gu... |