罗米鲁曲结构式
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常用名 | 罗米鲁曲 | 英文名 | Lomeguatrib |
|---|---|---|---|---|
| CAS号 | 192441-08-0 | 分子量 | 326.172 | |
| 密度 | 1.9±0.1 g/cm3 | 沸点 | 683.8±65.0 °C at 760 mmHg | |
| 分子式 | C10H8BrN5OS | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 367.3±34.3 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Effect of lomeguatrib-temozolomide combination on MGMT promoter methylation and expression in primary glioblastoma tumor cells.
Tumour Biol. 34(3) , 1935-47, (2013) Temozolomide (TMZ) is commonly used in the treatment of glioblastoma (GBM). The MGMT repair enzyme (O (6)-methylguanine-DNA methyltransferase) is an important factor causing chemotherapeutic resistance. MGMT prevents the formation of toxic effects of alkyl ad... |
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Randomized trial of the combination of lomeguatrib and temozolomide compared with temozolomide alone in chemotherapy naive patients with metastatic cutaneous melanoma.
J. Clin. Oncol. 25(18) , 2540-5, (2007) To evaluate tumor response, pharmacodynamic effects, and safety of a combination of lomeguatrib (LM), an O6-methylguanine DNA-methyltransferase (MGMT) inactivator, and temozolomide (TMZ), TMZ alone, and LM/TMZ after disease progression on TMZ alone in patient... |
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[Analysis of the relevant factors of mechanism for telozolomide chemoresistance].
Zhonghua Zhong Liu Za Zhi 33(10) , 794-6, (2011)
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Inhibition of DNA repair with MGMT pseudosubstrates: phase I study of lomeguatrib in combination with dacarbazine in patients with advanced melanoma and other solid tumours.
Br. J. Cancer 105(6) , 773-7, (2011) The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) reverses the O6-methylguanine (O6-meG) lesion induced by dacarbazine. Depletion of MGMT can be achieved using O6-meG pseudosubstrates. Herein, we report the first phase I experience of the n... |
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Novel role of triazenes in haematological malignancies: pilot study of Temozolomide, Lomeguatrib and IL-2 in the chemo-immunotherapy of acute leukaemia.
DNA Repair (Amst.) 6(8) , 1179-86, (2007) Previous studies indicated that dacarbazine and Temozolomide could be highly effective against refractory acute leukaemia. Their activity relies mainly on the generation of methyl adducts at the O(6)-position of guanine in DNA. High levels of O(6)-methylguani... |
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A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer.
Br. J. Cancer 98(10) , 1614-8, (2008) To evaluate the tumour response to lomeguatrib and temozolomide (TMZ) administered for 5 consecutive days every 4 weeks in patients with metastatic colorectal carcinoma. Patients with stage IV metastatic colorectal carcinoma received lomeguatrib (40 mg) and T... |
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MGMT inhibitors--The Trinity College-Paterson Institute experience, a chemist's perception.
DNA Repair (Amst.) 6(8) , 1161-9, (2007) The DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase (MGMT) can confer resistance to the cancer chemotherapeutic effects of the class of DNA damaging drugs generally referred to as the O(6)-alkylating agents. Inactivation of MGMT is thus a practical... |
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A phase I trial of lomeguatrib and irinotecan in metastatic colorectal cancer.
Cancer Chemother. Pharmacol. 66(5) , 829-35, (2010) Expression of the DNA repair protein O (6)-methylguanine-DNA methyltransferase (MGMT) correlates with resistance to irinotecan in colorectal cancer cell lines. This phase I study evaluated the maximum tolerated dose (MTD) of lomeguatrib, an inactivating pseud... |