蟾毒灵
蟾毒灵结构式
|
常用名 | 蟾毒灵 | 英文名 | Bufalin |
|---|---|---|---|---|
| CAS号 | 465-21-4 | 分子量 | 386.524 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 556.6±50.0 °C at 760 mmHg | |
| 分子式 | C24H34O4 | 熔点 | 242 - 243ºC | |
| MSDS | 中文版 美版 | 闪点 | 189.0±23.6 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
|
Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathways.
Am. J. Chin. Med. 42(3) , 729-42, (2014) Bufalin is a key component of a Chinese medicine (Chan Su) and has been proved effective in killing various cancer cells. Its role in inducing DNA damage and the inhibition of the DNA damage response (DDR) has been reported, but none have studied such action ... |
|
|
Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide.
Sci. Rep. 5 , 17047, (2015) Sodium taurocholate cotransporting polypeptide (NTCP) has been reported as a functional receptor for hepatitis B virus (HBV) infection. However, HBV could not efficiently infect HepG2 cells expressing NTCP (NTCP-HepG2 cells) under adherent monolayer-cell cond... |
|
|
Reversal effect of bufalin on multidrug resistance in K562/VCR vincristine-resistant leukemia cell line.
J. Tradit. Chin. Med. 34(6) , 678-83, (2014) To probe insights into the reversal effect of bufalin on vincristine-acquired multidrug resistance (MDR) in human leukemia cell line K562/VCR.Proliferative inhibition rate and the reversal index (RI) of bufalin were determined by Methyl thiazolyl tetrazolium ... |
|
|
Bufalin enhances TRAIL-induced apoptosis by redistributing death receptors in lipid rafts in breast cancer cells.
Anticancer Drugs 25(6) , 683-9, (2014) Studies have shown that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in cancer cells. However, breast cancer cells are generally resistant to TRAIL. In the present study, we explored the effect of bufalin on TR... |
|
|
Bufalin induces cell cycle arrest and apoptosis in gallbladder carcinoma cells.
Tumour Biol. 35(11) , 10931-41, (2014) Bufalin, a major digoxin-like immunoreactive component of the Chinese medicine Chan Su, has been shown to exert a potential for anticancer activity against various human cancer cell lines in vitro. However, no detailed studies have so far been reported on its... |
|
|
miR-155-5p antagonizes the apoptotic effect of bufalin in triple-negative breast cancer cells.
Anticancer Drugs 27 , 9-16, (2015) Bufalin, a cardiotonic steroid isolated from toad venom, has been shown to kill various types of tumor cells. Our previous study showed that triple-negative breast cancer (TNBC) cells were less sensitive to bufalin than other types of breast cancer cells, but... |
|
|
ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells.
J. Virol. 89(8) , 4434-48, (2015) In addition to transporting ions, the multisubunit Na(+),K(+)-ATPase also functions by relaying cardiotonic steroid (CTS)-binding-induced signals into cells. In this study, we analyzed the role of Na(+),K(+)-ATPase and, in particular, of its ATP1A1 α subunit ... |
|
|
Secreted protein acidic and rich in cysteine antagonizes bufalin-induced apoptosis in gastric cancer cells.
Mol. Med. Report. 12 , 2926-32, (2015) Bufalin is an active compound in the traditional Chinese medicine Chan Su, which has been shown to induce apoptosis in a range of cancer cell types. However, certain gastric cancer cells are known to be resistant to bufalin. Intracellular secreted protein aci... |
|
|
Preparation of bufalin-loaded pluronic polyetherimide nanoparticles, cellular uptake, distribution, and effect on colorectal cancer.
Int. J. Nanomedicine 9 , 4035-41, (2014) A large number of studies have shown that bufalin can have a significant antitumor effect in a variety of tumors. However, because of toxicity, insolubility in water, fast metabolism, short half-life, and other shortcomings, its application is limited in canc... |
|
|
Bufalin, a bioactive component of the Chinese medicine chansu, inhibits inflammation and invasion of human rheumatoid arthritis fibroblast-like synoviocytes.
Inflammation 37(4) , 1050-8, (2014) Rheumatoid arthritis fibroblast-like synoviocytes (RAFLSs) contribute to the destruction of cartilage and bone by production of metalloproteinases (MMPs) into the synovial fluid and by direct invasion into extracellular matrix (ECM). Bufalin, a major componen... |