D-甲瓦龙酸酯
D-甲瓦龙酸酯结构式
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常用名 | D-甲瓦龙酸酯 | 英文名 | D-Mevalonolactone |
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| CAS号 | 19115-49-2 | 分子量 | 130.14200 | |
| 密度 | 1.189g/cm3 | 沸点 | 274.9ºC at 760 mmHg | |
| 分子式 | C6H10O3 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 110ºC |
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Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones.
Bioorg. Med. Chem. 17(23) , 7915-23, (2009) A novel series of 2-cyclopropyl-4-thiophenyl quinoline-based mevalonolactones were synthesized from the substituted anilines by several reactions. Among them, (4R,6S)-6-[(E)-2-(2-cyclopropyl-6-fluoro-4-(4-fluoro-thiophenyl)-quinoline-3-yl)-ethenyl]-3,4,5,6-te... |
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Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS.
J. Lipid Res. 48(5) , 1212-20, (2007) We have developed a new sensitive and specific nonradioisotope assay method to measure the activity of HMG-CoA reductase, the rate-controlling enzyme in the cholesterol biosynthetic pathway. This method was based upon a stable isotope dilution technique by li... |
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Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS.
Anal. Biochem. 329(1) , 28-34, (2004) We present an integrated consolidation of previously reported methods for screening hydroxymethylglutaryl-coenzyme A reductase (HMGR) inhibitors in 96-well microtiter plates with rapid workup using established mammalian cell lines and liquid chromatography-ma... |
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4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway.
J. Chem. Ecol. 31(6) , 1381-400, (2005) 4,8-Dimethyldecanal (4,8-DMD) is the aggregation pheromone produced by male red flour beetles (RFB), Tribolium castaneum. To elucidate the biosynthetic origin of 4,8-DMD, the following studies were performed: (1) effects of juvenile hormone (JH) III, and path... |
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Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells.
Exp. Biol. Med. (Maywood.) 236(5) , 604-13, (2011) The diterpene geranylgeraniol (all trans-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-ol) suppresses the growth of human liver, lung, ovary, pancreas, colon, stomach and blood tumors with undefined mechanisms. We evaluated the growth-suppressive activity... |
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Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
J. Lipid Res. 49(12) , 2620-6, (2008) The aim of this study was to investigate the possible existence and magnitude of stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR). The catalytic portion of HMGR was expressed and purified. The reaction produ... |
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Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2.
Biochem. Cell Biol. 84(1) , 102-11, (2006) Monoterpenes have multiple pharmacological effects on the metabolism of mevalonate. Geraniol, a dietary monoterpene, has in vitro and in vivo anti-tumor activity against several cell lines. We have studied the effects of geraniol on growth, fatty-acid metabol... |
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[Mevalonolactone: a volatile compound produced by Psammotettix alienus (Dhb)].
C R Biol. 325(9) , 941-6, (2002) The interaction between the aphid Rhopalosiphum padi (L.) and the leafhopper Psammotettix alienus was investigated in the laboratory. The leafhoppers, when physically separated from aphid but with a common air supply, caused a reduction in aphid offspring pro... |
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Isoprenoids are essential for fruiting body formation in Myxococcus xanthus.
J. Bacteriol. 191 , 5849-5853, (2009) It was recently shown that Myxococcus xanthus harbors an alternative and reversible biosynthetic pathway to isovaleryl coenzyme A (CoA) branching from 3-hydroxy-3-methylglutaryl-CoA. Analyses of various mutants in these pathways for fatty acid profiles and fr... |
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Leukaemia inhibitory factor or oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication.
Biochem. Biophys. Res. Commun. 313(4) , 926-30, (2004) Leukaemia inhibitory factor (LIF) or Oncostatin M (OSM), both mitogens for Swiss mouse 3T3 cells, triggers initiation of DNA synthesis without the requirement for mevalonic acid. Thus, Lovastatin (LOV), an inhibitor of the hydroxy methylglutaryl CoA (HMGCoA) ... |