昂丹司琼盐酸盐二水合物
昂丹司琼盐酸盐二水合物结构式
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常用名 | 昂丹司琼盐酸盐二水合物 | 英文名 | Ondansetron hydrochloride |
|---|---|---|---|---|
| CAS号 | 103639-04-9 | 分子量 | 365.85 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 267.0±9.0 °C at 760 mmHg | |
| 分子式 | C18H24ClN3O3 | 熔点 | 231-232ºC | |
| MSDS | 中文版 美版 | 闪点 | 144.9±5.1 °C | |
| 符号 |
GHS05, GHS06, GHS09 |
信号词 | Danger |
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Utility of cerebrospinal fluid drug concentration as a surrogate for unbound brain concentration in nonhuman primates.
Drug Metab. Pharmacokinet. 29(5) , 419-26, (2014) In central nervous system drug discovery, cerebrospinal fluid (CSF) drug concentration (C(CSF)) has been widely used as a surrogate for unbound brain concentrations (C(u,brain)). However, previous rodent studies demonstrated that when drugs undergo active eff... |
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Pharmacological action of DA-9701 on the motility of feline stomach circular smooth muscle.
Pharmazie 70(3) , 183-92, (2015) DA-9701, a new prokinetic agent for the treatment of functional dyspepsia, is formulated with Pharbitis semen and Corydalis tuber. This study wasconducted to determine the pharmacological action of DA-9701 and to identify the receptors involved in DA-9701 -in... |
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Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP).
BMC Pharmacol. Toxicol. 14 , 20, (2013) Paracetamol (acetaminophen) poisoning remains the commonest cause of acute liver injury in Europe and North America. The intravenous (IV) N-acetylcysteine (NAC) regimen introduced in the 1970s has continued effectively unchanged. This involves 3 different inf... |
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Antiemetics added to phenylephrine infusion during cesarean delivery: a randomized controlled trial.
Obstet. Gynecol. 121(3) , 615-23, (2013) To estimate whether the addition of metoclopramide or its combination with ondansetron to a prophylactic phenylephrine infusion provides improved intraoperative nausea and vomiting prophylaxis compared with phenylephrine infusion alone.Women scheduled for ele... |
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Pharmacological evaluation of the anxiolytic-like effects of EMD 386088, a partial 5-HT6 receptor agonist, in the rat elevated plus-maze and Vogel conflict tests.
Neuropharmacology 85 , 253-62, (2014) The 5-HT6 is one of the most recent additions to the 5-HT receptor family. Its pharmacological profile and anatomical distribution is suggestive of a putative role in mood disorders. Most of preclinical evidence suggests an anxiolytic-like action of 5-HT6 rec... |
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Antidepressant and anxiolytic-like effects of 4n, a novel 5-HT3 receptor antagonist using behaviour based rodent models.
Indian J. Exp. Biol. 50(9) , 625-32, (2012) The present study was designed to investigate the putative antidepressant and anxiolytic-like effects of N-n-Butylquinoxalin-2-carboxamide (4n), a novel 5-HT3 receptor antagonist, with an optimal log P (2.01) and pA2 value (7.3) greater than ondansetron (6.9)... |
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Atrial stretch delays gastric emptying of liquids in awake rats.
Life Sci. 92(10) , 569-75, (2013) We previously reported that mechanical atrial stretch (AS) by balloon distention increased gastric tonus in anesthetized rats. The present study evaluated the effect of AS on the gastric emptying of a liquid test meal in awake rats and its underlying neural m... |
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Molecular changes in the medial prefrontal cortex and nucleus accumbens are associated with blocking the behavioral sensitization to cocaine.
Sci. Rep. 5 , 16172, (2015) Previous studies have demonstrated that cocaine-induced behavioral sensitization is associated with persistent functional and structural alterations in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc); however, the molecular mechanisms underlyi... |
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Pharmacokinetic drug interactions between ondansetron and tamoxifen in female Sprague-Dawley rats with DMBA-induced mammary tumor.
Anticancer Res. 33(2) , 521-8, (2013) Tamoxifen, which is used to treat breast cancer, and ondansetron, used for the treatment of chemotherapy-induced nausea, are commonly metabolized via cytochrome P450 (CYP) 2D subfamily and 3A1/2 in rats, as in humans. This study was conducted to investigate t... |
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A pilot study of full-dose ondansetron to treat heavy-drinking men withdrawing from alcohol in Brazil.
Addict. Behav. 38(4) , 2044-51, (2013) Ondansetron has emerged as a promising medication for the treatment of alcohol dependence, mainly among early-onset alcoholics. This research primarily aimed to evaluate the efficacy and safety of ondansetron at a 16mg/day dosage to treat alcohol-dependent ou... |