五氟利多
五氟利多结构式
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常用名 | 五氟利多 | 英文名 | Penfluridol |
|---|---|---|---|---|
| CAS号 | 26864-56-2 | 分子量 | 523.965 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 587.7±50.0 °C at 760 mmHg | |
| 分子式 | C28H27ClF5NO | 熔点 | 105-107ºC | |
| MSDS | 中文版 美版 | 闪点 | 309.2±30.1 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Adrenal fasciculata cells express T-type and rapidly and slowly activating L-type Ca2+ channels that regulate cortisol secretion.
Am. J. Physiol. Cell Physiol. 308 , C899-918, (2015) In whole cell patch-clamp recordings, we characterized the L-type Ca(2+) currents in bovine adrenal zona fasciculata (AZF) cells and explored their role, along with the role of T-type channels, in ACTH- and angiotensin II (ANG II)-stimulated cortisol secretio... |
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In vitro and in vivo properties of ellagic acid in malaria treatment.
Antimicrob. Agents Chemother. 53 , 1100-6, (2009) Malaria is one of the most significant causes of infectious disease in the world. The search for new antimalarial chemotherapies has become increasingly urgent due to the parasites' resistance to current drugs. Ellagic acid is a polyphenol found in various pl... |
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Penfluridol for schizophrenia.
Cochrane Database Syst. Rev. (2) , CD002923, (2006) Penfluridol, available since 1970, is an unusual long acting oral antipsychotic agent for the treatment of schizophrenia. It may be considered a depot medication as it is administered once a week.To review the effects of penfluridol for treatment of those wit... |
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Brief psychotic disorder associated with Sturge-Weber syndrome.
Eur. Psychiatry 20(4) , 356-7, (2005)
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Preferential block of T-type calcium channels by neuroleptics in neural crest-derived rat and human C cell lines.
Mol. Pharmacol. 42(2) , 364-72, (1992) We have used the whole-cell version of the patch-clamp technique to analyze the inhibition of Ca2+ currents by antipsychotic agents in neural crest-derived rat and human thyroid C cell lines. Diphenylbutylpiperidine (DPBP) antipsychotics, including penflurido... |
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T-type Ca2+ channels are required for adrenocorticotropin-stimulated cortisol production by bovine adrenal zona fasciculata cells.
Mol. Endocrinol. 7(8) , 1031-40, (1993) The function of low voltage-activated T-type Ca2+ channels in ACTH-stimulated cortisol production by bovine adrenal zona fasciculata cells (AZF) was explored in patch clamp and secretion studies. Nearly all AZF cells expressed only a low voltage-activated T-t... |
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Roles of intracellular and extracellular calcium in the kinetic profile of adrenocorticotropin secretion by perifused rat anterior pituitary cells. I. Corticotropin-releasing factor stimulation.
Endocrinology 126(2) , 849-57, (1990) We examined the effects of removing extracellular Ca2+ (Ca2+e), depleting intracellular Ca2+ (Ca2+i), inhibiting Ca2(+)-dependent calmodulin, blocking voltage-sensitive Ca2+ channels, and combining Ca2+i depletion with exposure to glucocorticoid on the secret... |
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Reversal of mefloquine resistance with penfluridol in isolates of Plasmodium falciparum from south-west Nigeria.
Trans. R. Soc. Trop. Med. Hyg. 87(1) , 81-3, (1993) The susceptibilities of isolates of Plasmodium falciparum from Nigeria and two reference cloned strains (D6 and W2) to mefloquine or chloroquine alone and in combination with either penfluridol, a piperidine analogue, or verapamil were determined using a modi... |
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Roles of intracellular and extracellular calcium in the kinetic profile of adrenocorticotropin secretion by perifused rat anterior pituitary cells. II. Arginine vasopressin, oxytocin, and angiotensin-II stimulation.
Endocrinology 126(2) , 858-68, (1990) We examined the effects of removing extracellular Ca2+ (Ca2+e), depleting intracellular Ca2+ (Ca2+i), inhibiting cAMP-dependent calmodulin, and blocking voltage-sensitive Ca2+ channels on the secretion of ACTH by perifused dispersed rat anterior pituitary cel... |
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The chemotherapy of rodent malaria. XLVI. Reversal of mefloquine resistance in rodent Plasmodium.
Ann. Trop. Med. Parasitol. 85(1) , 5-10, (1991) Multiple drug resistance in Plasmodium falciparum is already showing evidence of extending to mefloquine, which at present is one of the few alternative antimalarials for the prevention or treatment of infection with such parasites. Neither verapamil nor cypr... |