胆固醇琥珀酸单酯
胆固醇琥珀酸单酯结构式
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常用名 | 胆固醇琥珀酸单酯 | 英文名 | 4-[(3β)-Cholest-5-en-3-yloxy]-4-oxobutanoic acid |
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| CAS号 | 1510-21-0 | 分子量 | 486.73 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 586.0±43.0 °C at 760 mmHg | |
| 分子式 | C31H50O4 | 熔点 | 178 °C | |
| MSDS | 中文版 美版 | 闪点 | 179.6±21.7 °C |
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Co-expression of human agouti-related protein enhances expression and stability of human melanocortin-4 receptor.
Biochem. Biophys. Res. Commun. 456(1) , 116-21, (2014) G protein-coupled receptors (GPCRs) represent the largest family of transmembrane signaling proteins, and they are considered major targets of approximately half of all therapeutic agents. Human melanocortin-4 receptor (hMC4R) plays an important role in the c... |
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Solution structure of the transmembrane 2 domain of the human melanocortin-4 receptor in sodium dodecyl sulfate (SDS) micelles and the functional implication of the D90N mutant.
Biochim. Biophys. Acta 1848 , 1294-302, (2015) The melanocortin receptors (MCRs) are members of the G protein-coupled receptor (GPCR) 1 superfamily with seven transmembrane (TM) domains. Among them, the melanocortin-4 receptor (MC4R) subtype has been highlighted recently by genetic studies in obese humans... |
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Structural basis for the facilitative diffusion mechanism by SemiSWEET transporter.
Nat. Commun. 6 , 6112, (2015) SWEET family proteins mediate sugar transport across biological membranes and play crucial roles in plants and animals. The SWEETs and their bacterial homologues, the SemiSWEETs, are related to the PQ-loop family, which is characterized by highly conserved pr... |
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Kinetics of the early events of GPCR signalling.
FEBS Lett. 588(24) , 4701-7, (2014) Neurotensin receptor type 1 (NTS1) is a G protein-coupled receptor (GPCR) that affects cellular responses by initiating a cascade of interactions through G proteins. The kinetic details for these interactions are not well-known. Here, NTS1-nanodisc-Gαs and Gα... |
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G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent.
Biosci. Rep. 35 , (2015) G-protein coupled receptors (GPCRs) constitute the largest class of membrane proteins and are a major drug target. A serious obstacle to studying GPCR structure/function characteristics is the requirement to extract the receptors from their native environment... |
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Pharmacological Analysis and Structure Determination of 7-Methylcyanopindolol-Bound β1-Adrenergic Receptor.
Mol. Pharmacol. 88 , 1024-34, (2015) Comparisons between structures of the β1-adrenergic receptor (AR) bound to either agonists, partial agonists, or weak partial agonists led to the proposal that rotamer changes of Ser(5.46), coupled to a contraction of the binding pocket, are sufficient to inc... |
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Liposome-encapsulated CpG enhances antitumor activity accompanying the changing of lymphocyte populations in tumor via intratumoral administration.
Nucleic Acid Ther. 25(2) , 95-102, (2015) Although oligodeoxynucleotides containing CpG motifs (CpG-ODN) are potent immune stimulators, the use of natural CpG-ODN--phosphodiester-backbone CpG--has been limited due to its instability by nuclease in vivo. The aim of this study is to investigate the ant... |
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Enhanced pH-Responsiveness, Cellular Trafficking, Cytotoxicity and Long-circulation of PEGylated Liposomes with Post-insertion Technique Using Gemcitabine as a Model Drug.
Pharm. Res. 32 , 2428-38, (2015) The in vitro and in vivo properties of PEGylated pH-sensitive liposomes (PSL) prepared by pre- and post-insertion techniques were investigated.A pre-insertion or post-insertion technique was used for PSL PEGylation. For the first time, confocal laser scanning... |
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Anginex lipoplexes for delivery of anti-angiogenic siRNA.
Int. J. Pharm. 472(1-2) , 175-84, (2014) Angiogenesis is one of the hallmarks of cancer which renders it an attractive target for therapy of malignancies. Tumor growth suppression can be achieved by inhibiting angiogenesis since it would deprive tumor cells of oxygen and vital nutrients. Activation ... |
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Molecular Determinants of CGS21680 Binding to the Human Adenosine A2A Receptor.
Mol. Pharmacol. 87 , 907-15, (2015) The adenosine A2A receptor (A(2A)R) plays a key role in transmembrane signaling mediated by the endogenous agonist adenosine. Here, we describe the crystal structure of human A2AR thermostabilized in an active-like conformation bound to the selective agonist ... |