5'-N-乙基酰胺基腺苷
5'-N-乙基酰胺基腺苷结构式
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常用名 | 5'-N-乙基酰胺基腺苷 | 英文名 | NECA |
|---|---|---|---|---|
| CAS号 | 35920-39-9 | 分子量 | 308.293 | |
| 密度 | 1.9±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C12H16N6O4 | 熔点 | 229-231ºC | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS06 |
信号词 | Danger |
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Multivalent site-specific phage modification enhances the binding affinity of receptor ligands.
Bioconjug. Chem. 26(3) , 529-36, (2015) High-throughput screening of combinatorial chemical libraries is a powerful approach for identifying targeted molecules. The display of combinatorial peptide libraries on the surface of bacteriophages offers a rapid, economical way to screen billions of pepti... |
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A2b adenosine signaling represses CIITA transcription via an epigenetic mechanism in vascular smooth muscle cells.
Biochim. Biophys. Acta 1849 , 665-76, (2015) Chronic inflammation plays a major role in the pathogenesis of atherosclerosis. Vascular smooth muscle cells (VSMC), by expressing and presenting major histocompatibility complex II (MHC II) molecules, help recruit T lymphocyte and initiate the inflammatory r... |
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G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent.
Biosci. Rep. 35 , (2015) G-protein coupled receptors (GPCRs) constitute the largest class of membrane proteins and are a major drug target. A serious obstacle to studying GPCR structure/function characteristics is the requirement to extract the receptors from their native environment... |
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Effect of a toggle switch mutation in TM6 of the human adenosine A₃ receptor on Gi protein-dependent signalling and Gi-independent receptor internalization.
Br. J. Pharmacol. 171(16) , 3827-44, (2014) The highly conserved tryptophan (W6.48) in transmembrane domain 6 of GPCRs has been shown to play a central role in forming an active conformation in response to agonist binding. We set out to characterize the effect of this mutation on the efficacy of two ag... |
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A2A Adenosine Receptor Regulates the Human Blood-Brain Barrier Permeability.
Mol. Neurobiol. 52 , 664-78, (2015) The blood-brain barrier (BBB) symbolically represents the gateway to the central nervous system. It is a single layer of specialized endothelial cells that coats the central nervous system (CNS) vasculature and physically separates the brain environment from ... |
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Scanning mutagenesis in a yeast system delineates the role of the NPxxY(x)(5,6)F motif and helix 8 of the adenosine A(2B) receptor in G protein coupling.
Biochem. Pharmacol. 95 , 290-300, (2015) The adenosine receptor subfamily includes four subtypes: the A1, A2A, A2B and A3 receptors, which all belong to the superfamily of G protein-coupled receptors (GPCRs). The adenosine A2B receptor is the least investigated of the adenosine receptors, and the mo... |
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Involvement of cAMP-PKA pathway in adenosine A1 and A2A receptor-mediated regulation of acetaldehyde-induced activation of HSCs.
Biochimie 115 , 59-70, (2015) The present study was undertaken to investigate the mechanism by which adenosine receptors (ARs)-mediated the cAMP/PKA/CREB signal pathway regulates the activation of acetaldehyde-induced hepatic stellate cells (HSCs). Primary HSCs were isolated from SD rats,... |
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Adenosine A2A receptor, a potential valuable target for controlling reoxygenated DCs-triggered inflammation.
Mol. Immunol. 63(2) , 559-65, (2015) Dendritic cells (DCs) exposed to various oxygen tensions under physiopathological conditions are the critical immune cells linking innate and adaptive immunity. We have previously demonstrated that reoxygenation of hypoxia-differentiated DCs triggers complete... |
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Anti-inflammatory or proinflammatory effect of an adenosine receptor agonist on the Th17 autoimmune response is inflammatory environment-dependent.
J. Immunol. 193(11) , 5498-505, (2014) Adenosine is a key endogenous signaling molecule that regulates a wide range of physiological functions, including immune system function and inflammation. Studies have shown that adenosine receptor (AR) agonists can be either anti-inflammatory or proinflamma... |
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Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension.
Purinergic Signal. 11 , 519-31, (2015) The A(2B) adenosine receptor (AR) has emerged as a unique member of the AR family with contrasting roles during acute and chronic disease states. We utilized zinc-finger nuclease technology to create A(2B)AR gene (Adora2b)-disrupted rats on the Dahl salt-sens... |