硝碘酚腈结构式
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常用名 | 硝碘酚腈 | 英文名 | Nitroxynil |
|---|---|---|---|---|
| CAS号 | 1689-89-0 | 分子量 | 290.015 | |
| 密度 | 2.2±0.1 g/cm3 | 沸点 | 280.1±40.0 °C at 760 mmHg | |
| 分子式 | C7H3IN2O3 | 熔点 | 136 - 139ºC | |
| MSDS | 中文版 美版 | 闪点 | 123.2±27.3 °C | |
| 符号 |
GHS06, GHS09 |
信号词 | Danger |
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In vitro metabolism of aromatic nitriles.
J. Pharm. Sci. 83(12) , 1729-34, (1994) Studies on the metabolic fate of aromatic nitriles, in contrast to their aliphatic counterparts, have been minimal and the subject of controversy. The in vitro metabolic fate of several aromatic nitriles with varying substituents was investigated by using rat... |
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Efficacy of an injectable combination anthelmintic (nitroxynil+clorsulon+ivermectin) against early immature Fasciola hepatica compared to triclabendazole combination flukicides given orally or topically to cattle.
Vet. Parasitol. 162(3-4) , 278-84, (2009) The objective was to compare the efficacy against artificially induced 2- and 4-week old early immature triclabendazole-susceptible liver flukes (Fasciola hepatica) of an injectable combination of nitroxynil, clorsulon and ivermectin with oral and pour-on com... |
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Determination of nitroxynil residues in tissues using high-performance liquid chromatography-thermospray mass spectrometry.
Analyst 114(9) , 1013-5, (1989) A method is described for the determination of nitroxynil residues in muscle, liver and kidney. The samples were extracted into diethyl ether and cleaned-up using a simple liquid-liquid extraction step. Any nitroxynil present was separated from interfering co... |
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Ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo and in vitro drug treatment with nitroxynil (Trodax).
Parasitol. Res. 101(4) , 929-41, (2007) Male Sprague-Dawley rats were dosed orally with nitroxynil at a concentration of 40 mg/kg, and adult Fasciola hepatica were recovered after 24, 48 and 72 h. Fine structural changes to the tegument and gut were monitored by transmission electron microscopy. Fl... |
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Efficacy of nitroxynil against Fasciola hepatica resistant to triclabendazole in a naturally infected sheep flock.
Parasitol. Res. 107(5) , 1205-11, (2010) The aim of this study was to compare the efficacy of triclabendazole (TCBZ) and nitroxynil against a TCBZ-resistant Fasciola hepatica strain in a naturally infected sheep flock. The efficacies were measured by the faecal egg count reduction test. The level of... |
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Morphological response of triclabendazole-susceptible and triclabendazole-resistant isolates of Fasciola hepatica to treatment in vitro with nitroxynil (Trodax).
Parasitol. Res. 104(3) , 645-55, (2009) Adult liver flukes belonging to three isolates of differing sensitivity to triclabendazole were incubated for 24 h in vitro in nitroxynil at a concentration of 100 microg/ml. Fine structural changes to the tegument, sub-tegumental region and gut were assessed... |
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Voltammetric assay of the anthelmintic veterinary drug nitroxynil in bulk form and formulation at a mercury electrode.
J. Pharm. Biomed. Anal. 41(4) , 1268-73, (2006) The electrochemical behavior of the anthelmintic veterinary drug nitroxynil at the mercury electrode was studied in a series of Britton-Robinson universal buffer of pH 1.9-11 containing 20% (v/v) ethanol using dc-polarography cyclic voltammetry and controlled... |
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Efficacy of nitroxynil against ivermectin, benzimidazole and salicylanilide resistant H contortus.
Vet. Rec. 126(25) , 624-5, (1990)
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High-performance liquid chromatographic method for the determination of the anthelmintic nitroxynil in cattle muscle tissue with on-line anion-exchange clean-up.
J. Chromatogr. A. 613(2) , 347-53, (1993) A high-performance liquid chromatographic method for the determination of the anthelmintic nitroxynil has been developed. The drug was extracted from cattle muscle tissue with 1% triethylamine in acetonitrile. The extract was evaporated to dryness and taken u... |
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Combined subcutaneous administration of ivermectin and nitroxynil in sheep: age/body weight related changes to the kinetic disposition of both compounds.
Res. Vet. Sci. 88(2) , 315-20, (2010) The effect of age/body weight in the plasma disposition kinetics of ivermectin (IVM) and nitroxynil (NTX) after their co-administration as a combined formulation to sheep was studied. Sixteen (16) male sheep were allocated into two experimental groups (n=8 ea... |