甲硝唑
甲硝唑结构式
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常用名 | 甲硝唑 | 英文名 | Metronidazole |
|---|---|---|---|---|
| CAS号 | 443-48-1 | 分子量 | 171.154 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 405.4±25.0 °C at 760 mmHg | |
| 分子式 | C6H9N3O3 | 熔点 | 159-161 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 199.0±23.2 °C | |
| 符号 |
GHS08 |
信号词 | Warning |
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A trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosis.
PLoS ONE 9(4) , e93953, (2014) Trisubstituted benzimidazoles have demonstrated potency against Gram-positive and Gram-negative bacterial pathogens. Previously, a library of novel trisubstituted benzimidazoles was constructed for high throughput screening, and compounds were identified that... |
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Indirect electroreduction as pretreatment to enhance biodegradability of metronidazole.
J. Hazard. Mater. 278 , 172-9, (2014) The removal of metronidazole, a biorecalcitrant antibiotic, by coupling an electrochemical reduction with a biological treatment was examined. Electroreduction was performed in a home-made flow cell at -1.2V/SCE on graphite felt. After only one pass through t... |
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Carrier Mediated Distribution System (CAMDIS): a new approach for the measurement of octanol/water distribution coefficients.
Eur. J. Pharm. Sci. 68 , 68-77, (2015) Here we present a miniaturized assay, referred to as Carrier-Mediated Distribution System (CAMDIS) for fast and reliable measurement of octanol/water distribution coefficients, log D(oct). By introducing a filter support for octanol, phase separation from wat... |
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Determination of nitroimidazole residues in aquaculture tissue using ultra high performance liquid chromatography coupled to tandem mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 960 , 105-15, (2014) An UHPLC-MS/MS method was developed for the quantitative confirmatory analysis of residues of nitroimidazole drugs (dimetridazole, ipronidazole, metronidazole, ornidazole and ronidazole) and their corresponding hydroxy metabolites (HMMNI, ipronidazile-OH and ... |
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Antibiotic exposure in a low-income country: screening urine samples for presence of antibiotics and antibiotic resistance in coagulase negative staphylococcal contaminants.
PLoS ONE 9(12) , e113055, (2014) Development of antimicrobial resistance has been assigned to excess and misuse of antimicrobial agents. Staphylococci are part of the normal flora but are also potential pathogens that have become essentially resistant to many known antibiotics. Resistances i... |
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Azole antifungal inhibition of buprenorphine, methadone and oxycodone in vitro metabolism.
J. Anal. Toxicol. 39 , 374-86, (2015) Opioid-related mortality rates have escalated. Drug interactions may increase blood concentrations of the opioid. We therefore used human liver microsomes (HLMs) and cDNA-expressed human cytochrome P450s (rCYPs) to study in vitro inhibition of buprenorphine m... |
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Fast targeted analysis of 132 acidic and neutral drugs and poisons in whole blood using LC-MS/MS.
Forensic Sci. Int. 243 , 35-43, (2014) The aim of this study was to develop an LC-MS/MS based screening technique that covers a broad range of acidic and neutral drugs and poisons by combining a small sample volume and efficient extraction technique with simple automated data processing. After pro... |
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Gingival pain: an unusual side effect of ziprasidone.
BMJ Case Rep. 2013 , doi:10.1136/bcr-2012-007577, (2013) The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laboratory findings were unremarkable. He did not have any extra-pyr... |
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Anti-Helicobacter pylori, gastroprotective, anti-inflammatory, and cytotoxic activities of methanolic extracts of five different populations of Hippocratea celastroides collected in Mexico.
J. Ethnopharmacol. 155(2) , 1156-63, (2014) The root barks of Hippocratea celastroides have been used for decades in Mexican traditional medicine to treat gastritis and ulcers. To investigate the anti-Helicobacter pylori, gastroprotective, anti-inflammatory, and cytotoxic activities of methanolic extra... |
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In vitro antibacterial activity of AZD0914, a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-Negative, and atypical bacteria.
Antimicrob. Agents Chemother. 59(1) , 467-74, (2014) AZD0914 is a new spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor with potent in vitro antibacterial activity against key Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, and... |